Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 2204971..2205616 Replicon chromosome
Accession NZ_CP075135
Organism Salmonella enterica strain CFSAN044888

Toxin (Protein)


Gene name hicA Uniprot ID A0A5Z7XAV3
Locus tag A7S10_RS10715 Protein ID WP_070800844.1
Coordinates 2205434..2205616 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A5Z7XCZ9
Locus tag A7S10_RS10710 Protein ID WP_058645148.1
Coordinates 2204971..2205405 (-) Length 145 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S10_RS10695 (2200078) 2200078..2200815 + 738 WP_070800968.1 C40 family peptidase -
A7S10_RS10700 (2200713) 2200713..2201420 + 708 WP_070799599.1 tail assembly protein -
A7S10_RS10705 (2201491) 2201491..2204904 + 3414 WP_259404205.1 host specificity protein J -
A7S10_RS10710 (2204971) 2204971..2205405 - 435 WP_058645148.1 transcriptional regulator Antitoxin
A7S10_RS10715 (2205434) 2205434..2205616 - 183 WP_070800844.1 type II toxin-antitoxin system HicA family toxin Toxin
A7S10_RS10720 (2205705) 2205705..2206586 + 882 WP_070794208.1 prophage tail fiber N-terminal domain-containing protein -
A7S10_RS10725 (2206597) 2206597..2207190 + 594 WP_065314116.1 DUF4376 domain-containing protein -
A7S10_RS10730 (2207298) 2207298..2207672 + 375 WP_058645172.1 DUF1353 domain-containing protein -
A7S10_RS10735 (2207949) 2207949..2208212 - 264 WP_058645171.1 hypothetical protein -
A7S10_RS10740 (2208212) 2208212..2210302 - 2091 WP_181377589.1 colicin-like bacteriocin tRNase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2165217..2218469 53252


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(11-82)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6892.08 Da        Isoelectric Point: 10.4804

>T203204 WP_070800844.1 NZ_CP075135:c2205616-2205434 [Salmonella enterica]
MKYNEFRRWLIQQGAKFINAPDGGSHQRVILNGKESVFPCHGAKEMPEPLRKKILKDLGL

Download         Length: 183 bp

>T203204 NZ_CP099892:3482350-3482568 [Escherichia albertii]
ATGTCCGATAAACCTTTAACAAAAACCGATTATTTGATGCGTCTGCGTCGTTGCCAGACAATTGACACACTGGAACGTGT
TATCGAGAAAAATAAATATGAATTATCAGATAATGAATTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTTGCAGAGC
TGACTATGAATAAGCTATATGACAAGATCCCTTCCTCAGTGTGGAAATTCATTCGGTAA

Antitoxin


Download         Length: 145 a.a.        Molecular weight: 15777.18 Da        Isoelectric Point: 4.5833

>AT203204 WP_058645148.1 NZ_CP075135:c2205405-2204971 [Salmonella enterica]
MFNYAVKPEYDPATESWVVTCRDLPLFNSVSFSIDDALLEAVDGAIVALSIEIDARRPVPIASQPEEGEYVIHLPVLVVM
KAALHNAMISTGTRKSDLARTMGMKGPQIDRLLDVCHSSKVETVELALQQLNRTVQISVDNVAV

Download         Length: 435 bp

>AT203204 NZ_CP099892:3481950-3482324 [Escherichia albertii]
ATGGATGAATACTCACCAAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGTAACCATGGCTGGGTAAATGACCCAACCTCGGCAATCAATCTACAGCTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAACAGATTGATGAATATCTG
GACGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGCTCTTCAGAAATGGCGGAAGTCAGGTAACCGATT
GTTCCGTTGCTTTGTTAACGCCACCAAAGCGAATCCTGCAAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Z7XAV3

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z7XCZ9

References