Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 948895..949555 Replicon chromosome
Accession NZ_CP075135
Organism Salmonella enterica strain CFSAN044888

Toxin (Protein)


Gene name cptA Uniprot ID A0A3Y0E4E4
Locus tag A7S10_RS04590 Protein ID WP_000244757.1
Coordinates 949142..949555 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag A7S10_RS04585 Protein ID WP_000351186.1
Coordinates 948895..949161 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S10_RS04565 (944823) 944823..946256 - 1434 WP_001230152.1 6-phospho-beta-glucosidase BglA -
A7S10_RS04570 (946415) 946415..946726 + 312 WP_058344418.1 N(4)-acetylcytidine aminohydrolase -
A7S10_RS04575 (946890) 946890..947549 + 660 WP_000250289.1 hemolysin III family protein -
A7S10_RS04580 (947665) 947665..948645 - 981 WP_000874170.1 tRNA-modifying protein YgfZ -
A7S10_RS04585 (948895) 948895..949161 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
A7S10_RS04590 (949142) 949142..949555 + 414 WP_000244757.1 protein YgfX Toxin
A7S10_RS04595 (949608) 949608..950129 - 522 WP_001055885.1 flavodoxin FldB -
A7S10_RS04600 (950242) 950242..951138 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
A7S10_RS04605 (951162) 951162..951875 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
A7S10_RS04610 (951881) 951881..953614 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16282.29 Da        Isoelectric Point: 11.1741

>T203195 WP_000244757.1 NZ_CP075135:949142-949555 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISRQH

Download         Length: 414 bp

>T203195 NZ_CP099892:297375-297902 [Escherichia albertii]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTTTGCGAGCGTATATCCTTTGTAGCAACACTC
CAGAACGTCAGGTCCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTCACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCATTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCTCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCGTTGGTTGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACTAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT203195 WP_000351186.1 NZ_CP075135:948895-949161 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT203195 NZ_CP099892:297102-297368 [Escherichia albertii]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAATCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGTTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Y0E4E4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References