Detailed information of TA system TA203192

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1(toxin)
• Location: 4599537..4600153
• Replicon: chromosome
• Accession: NZ_CP075134
• Organism: Salmonella enterica subsp. enterica serovar Saintpaul strain CFSAN044909

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q8Z2U3
• Locus tag: A7S31_RS22295
• Protein ID: WP_000238494.1
• Coordinates: 4599537..4599911 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A8E9YHE9
• Locus tag: A7S31_RS22300
• Protein ID: WP_001523745.1
• Coordinates: 4599911..4600153 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7S31_RS22280 (4597039)	4597039..4597941	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
A7S31_RS22285 (4597938)	4597938..4598573	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
A7S31_RS22290 (4598570)	4598570..4599499	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
A7S31_RS22295 (4599537)	4599537..4599911	-	375	WP_000238494.1	type II toxin-antitoxin system VapC family toxin	Toxin
A7S31_RS22300 (4599911)	4599911..4600153	-	243	WP_001523745.1	CopG family transcriptional regulator	Antitoxin
A7S31_RS22305 (4600358)	4600358..4601287	+	930	WP_001523720.1	alpha/beta hydrolase	-
A7S31_RS22310 (4601373)	4601373..4601684	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
A7S31_RS22315 (4601681)	4601681..4602127	+	447	WP_001259012.1	type II toxin-antitoxin system HigA family antitoxin	-
A7S31_RS22320 (4602142)	4602142..4603083	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
A7S31_RS22325 (4603128)	4603128..4603565	-	438	WP_000560956.1	D-aminoacyl-tRNA deacylase	-
A7S31_RS22330 (4603562)	4603562..4604434	-	873	WP_001523799.1	virulence factor BrkB family protein	-
A7S31_RS22335 (4604428)	4604428..4605027	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-115)

Antitoxin

• Ribbon-helix-helix protein, CopG (13-47)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13908.18 Da
• Isoelectric Point: 7.3567

>T203192 WP_000238494.1 NZ_CP075134:c4599911-4599537 [Salmonella enterica subsp. enterica serovar Saintpaul]
MVKGSALFDTNILIDLFSGRIEAKHALEAYPPQNAISLITWMEVMVGAKKYHQENRTRIALSAFNIIGVTQEIAERSVIV
RQEYGMKLPDAIILATAQVHRCELVTRNTKDFADIPGVITPYHL

Nucleotide

• Length: 375 bp

>T203192 NZ_CP099891:8776-9192 [Escherichia albertii]
GTGAACAAGATCTATATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCACGTTCAGCTGGTTGACGCATTCTGTGAGCGACTCGATGCCGTCCTGCCCTGGGATCGCGCC
GCGGTGGATGCGACCACAGAGATTAAGGTGGCGCTGCGCCTCGCCGGAACGCCGATAGGCCCGAACGACACGGCGATTTC
CGGACACGCCATCGCGGCGGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGAGCGGGTTCCGGGCCTGATACTGG
AAGACTGGGCCGGTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9437.77 Da
• Isoelectric Point: 4.4463

>AT203192 WP_001523745.1 NZ_CP075134:c4600153-4599911 [Salmonella enterica subsp. enterica serovar Saintpaul]
MMAGMDMGRILLDLSDDVIKRLDDLKVQRNLPRAELLREAVEQYLERQDRAETTISKALGLWQGCEEDGVEYQRKLREEW

Nucleotide

• Length: 243 bp

>AT203192 NZ_CP099891:8549-8779 [Escherichia albertii]
ATGAGAACCGTATCGATATTTAAAAATGGCAACAACCGTGCCATCCGTCTGCCCCGGGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGGCAGCATCATCCTGCGTCCCGTCCGACCGACCTGGGGCTCGTTCGCGCAGCTCG
AAAAAGCTGACCCGGACTTTATGGCGGAGCGCGAGGACGTTATCAGCGACGAAGGACGATTTAACCTGTGA

Structures

Toxin

• AlphaFold DB: A0A5I6CND8