203191

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4294989..4295770 Replicon chromosome
Accession NZ_CP075134
Organism Salmonella enterica subsp. enterica serovar Saintpaul strain CFSAN044909

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag A7S31_RS20985 Protein ID WP_000626100.1
Coordinates 4294989..4295480 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag A7S31_RS20990 Protein ID WP_001110452.1
Coordinates 4295477..4295770 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S31_RS20950 (4290984) 4290984..4291559 + 576 WP_001188509.1 transcriptional regulator -
A7S31_RS20960 (4291830) 4291830..4291907 - 78 Protein_4125 helix-turn-helix domain-containing protein -
A7S31_RS20965 (4291998) 4291998..4292330 - 333 WP_001165472.1 MerR family transcriptional regulator -
A7S31_RS20970 (4292402) 4292402..4292779 + 378 WP_000916345.1 EthD family reductase -
A7S31_RS20975 (4293812) 4293812..4293886 + 75 Protein_4128 porin family protein -
A7S31_RS20980 (4293989) 4293989..4294741 + 753 WP_001524265.1 non-specific acid phosphatase -
A7S31_RS20985 (4294989) 4294989..4295480 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
A7S31_RS20990 (4295477) 4295477..4295770 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
A7S31_RS20995 (4296087) 4296087..4296308 + 222 WP_001576552.1 hypothetical protein -
A7S31_RS21000 (4296573) 4296573..4297448 + 876 WP_000921674.1 AraC family transcriptional regulator -
A7S31_RS21005 (4297445) 4297445..4297732 + 288 WP_001269916.1 transcriptional regulator RtsB -
A7S31_RS21010 (4297872) 4297872..4298120 + 249 Protein_4135 Ig-like domain-containing protein -
A7S31_RS23535 (4298232) 4298232..4298363 + 132 Protein_4136 hypothetical protein -
A7S31_RS21015 (4298658) 4298658..4299563 - 906 WP_043985912.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T203191 WP_000626100.1 NZ_CP075134:c4295480-4294989 [Salmonella enterica subsp. enterica serovar Saintpaul]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T203191 NZ_CP099890:4139155-4139433 [Escherichia albertii]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCAAGCTGTATTGCTGATATCGATATGCCCGGTTACCGACTAC
ACCCATTAAGCGGCGATCGCGATGGCATCTGGGCAATATCTGTATCAGGCAACTGGCGAATCACATTTGAGTTCGTCAAT
GGCAATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT203191 WP_001110452.1 NZ_CP075134:c4295770-4295477 [Salmonella enterica subsp. enterica serovar Saintpaul]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT203191 NZ_CP099890:4139433-4139717 [Escherichia albertii]
ATGAAAATGGTCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGACTGTTGACCGGAAAAGCGGCTTTGACGCCAGAAATGGCGA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCTGAG
AAAACGGTGGATGTGTCGCGGTTGCGCCGTCTGGTTACGCAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
AlphaFold DB A0A5I1DGA4

References