203190

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4163296..4163812 Replicon chromosome
Accession NZ_CP075134
Organism Salmonella enterica subsp. enterica serovar Saintpaul strain CFSAN044909

Toxin (Protein)


Gene name relE Uniprot ID A0A3U8PDE0
Locus tag A7S31_RS20315 Protein ID WP_000220575.1
Coordinates 4163296..4163580 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag A7S31_RS20320 Protein ID WP_000212724.1
Coordinates 4163570..4163812 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S31_RS20300 (4158412) 4158412..4160064 + 1653 WP_001523643.1 alpha,alpha-phosphotrehalase -
A7S31_RS20305 (4160473) 4160473..4162611 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
A7S31_RS20310 (4162828) 4162828..4163292 + 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
A7S31_RS20315 (4163296) 4163296..4163580 - 285 WP_000220575.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A7S31_RS20320 (4163570) 4163570..4163812 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
A7S31_RS20325 (4163890) 4163890..4165803 - 1914 WP_001523608.1 BglG family transcription antiterminator -
A7S31_RS20330 (4165820) 4165820..4166560 - 741 WP_001523583.1 KDGP aldolase family protein -
A7S31_RS20335 (4166557) 4166557..4167675 - 1119 WP_001523624.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
A7S31_RS20340 (4167659) 4167659..4168792 - 1134 WP_001523591.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10868.70 Da        Isoelectric Point: 10.0482

>T203190 WP_000220575.1 NZ_CP075134:c4163580-4163296 [Salmonella enterica subsp. enterica serovar Saintpaul]
MTYELEFDPRALKEWHKLGDTVKAQIKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T203190 NZ_CP099890:3834372-3834475 [Escherichia albertii]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAAAAC
AGGAATCGTTTTCGGTCTCTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT203190 WP_000212724.1 NZ_CP075134:c4163812-4163570 [Salmonella enterica subsp. enterica serovar Saintpaul]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT203190 NZ_CP099890:c3834477-3834245 [Escherichia albertii]
ATAAAAAGAGACCGAAAACGATTCCTGTTTTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTACAAAATGGTCAG
TAAAAAGCACGTCGACCACCGTCTTAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGTGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3U8PDE0

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References