Detailed information of TA system TA203186

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3456382..3457002
• Replicon: chromosome
• Accession: NZ_CP075134
• Organism: Salmonella enterica subsp. enterica serovar Saintpaul strain CFSAN044909

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: A7S31_RS16920
• Protein ID: WP_001280991.1
• Coordinates: 3456784..3457002 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: A7S31_RS16915
• Protein ID: WP_000344807.1
• Coordinates: 3456382..3456756 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7S31_RS16905 (3451521)	3451521..3452714	+	1194	WP_001039202.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-
A7S31_RS16910 (3452737)	3452737..3455886	+	3150	WP_058671868.1	efflux RND transporter permease AcrB	-
A7S31_RS16915 (3456382)	3456382..3456756	+	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
A7S31_RS16920 (3456784)	3456784..3457002	+	219	WP_001280991.1	HHA domain-containing protein	Toxin
A7S31_RS16925 (3457181)	3457181..3457732	+	552	WP_001524012.1	maltose O-acetyltransferase	-
A7S31_RS16930 (3457850)	3457850..3458320	+	471	WP_000136183.1	YlaC family protein	-
A7S31_RS16935 (3458376)	3458376..3458516	-	141	WP_001197749.1	type B 50S ribosomal protein L36	-
A7S31_RS16940 (3458522)	3458522..3458782	-	261	WP_000801415.1	type B 50S ribosomal protein L31	-
A7S31_RS16945 (3459007)	3459007..3460557	+	1551	WP_001523958.1	EAL domain-containing protein	-
A7S31_RS16955 (3460788)	3460788..3461177	+	390	WP_000961286.1	MGMT family protein	-
A7S31_RS16960 (3461210)	3461210..3461779	-	570	WP_001523942.1	YbaY family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T203186 WP_001280991.1 NZ_CP075134:3456784-3457002 [Salmonella enterica subsp. enterica serovar Saintpaul]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T203186 NZ_CP099890:2144332-2144859 [Escherichia albertii]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTTTGCGAGCGTATATCCTTTGCCGCAACACTC
CAGAATGTCAGGTCCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTCACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCATTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCTCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCGTTGGTTGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACTAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT203186 WP_000344807.1 NZ_CP075134:3456382-3456756 [Salmonella enterica subsp. enterica serovar Saintpaul]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT203186 NZ_CP099890:2144059-2144325 [Escherichia albertii]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAATCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGTTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0