Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1012854..1013668 Replicon chromosome
Accession NZ_CP075134
Organism Salmonella enterica subsp. enterica serovar Saintpaul strain CFSAN044909

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A5Z2DPT9
Locus tag A7S31_RS04830 Protein ID WP_001522912.1
Coordinates 1012854..1013381 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag A7S31_RS04835 Protein ID WP_000855694.1
Coordinates 1013378..1013668 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S31_RS04800 (1009056) 1009056..1009454 + 399 Protein_942 cytoplasmic protein -
A7S31_RS04805 (1009645) 1009645..1009884 + 240 Protein_943 hypothetical protein -
A7S31_RS04810 (1010041) 1010041..1010709 + 669 WP_000445914.1 hypothetical protein -
A7S31_RS04815 (1010736) 1010736..1011230 + 495 WP_001522903.1 hypothetical protein -
A7S31_RS04820 (1011475) 1011475..1012131 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
A7S31_RS04825 (1012358) 1012358..1012781 + 424 Protein_947 transposase -
A7S31_RS04830 (1012854) 1012854..1013381 - 528 WP_001522912.1 GNAT family N-acetyltransferase Toxin
A7S31_RS04835 (1013378) 1013378..1013668 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
A7S31_RS04840 (1013938) 1013938..1014138 - 201 Protein_950 transposase -
A7S31_RS04845 (1014542) 1014542..1014985 - 444 WP_001522905.1 SPI-1 type III secretion system invasion lipoprotein InvH -
A7S31_RS04850 (1015441) 1015441..1016091 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
A7S31_RS04855 (1016088) 1016088..1017776 + 1689 WP_000848101.1 type III secretion system outer membrane ring protein InvG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1012587..1012781 194


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19030.88 Da        Isoelectric Point: 9.1303

>T203176 WP_001522912.1 NZ_CP075134:c1013381-1012854 [Salmonella enterica subsp. enterica serovar Saintpaul]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGCLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQICDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T203176 NZ_CP099889:37236-37541 [Escherichia albertii]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGGGAAAATGACATCAAAAATGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT203176 WP_000855694.1 NZ_CP075134:c1013668-1013378 [Salmonella enterica subsp. enterica serovar Saintpaul]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT203176 NZ_CP099889:37016-37234 [Escherichia albertii]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGCTGCTCAAGGCGTATGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGGCGACTGCGCGCTGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCAG
AGGTCGCCAGGTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Z2DPT9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References