Detailed information of TA system TA203175

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 857042..857667
• Replicon: chromosome
• Accession: NZ_CP075134
• Organism: Salmonella enterica subsp. enterica serovar Saintpaul strain CFSAN044909

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: A7S31_RS04130
• Protein ID: WP_000911337.1
• Coordinates: 857269..857667 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: C0PXM4
• Locus tag: A7S31_RS04125
• Protein ID: WP_000557545.1
• Coordinates: 857042..857269 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7S31_RS04095 (852055)	852055..853572	+	1518	WP_000003339.1	lysine--tRNA ligase	-
A7S31_RS04100 (853648)	853648..854193	-	546	WP_000133994.1	isopentenyl-diphosphate Delta-isomerase	-
A7S31_RS04105 (854458)	854458..855216	+	759	WP_000244328.1	amidase activator ActS	-
A7S31_RS04115 (855501)	855501..856307	-	807	WP_010989071.1	DUF1460 domain-containing protein	-
A7S31_RS04120 (856582)	856582..856833	-	252	WP_001540858.1	hypothetical protein	-
A7S31_RS04125 (857042)	857042..857269	+	228	WP_000557545.1	toxin-antitoxin system antitoxin VapB	Antitoxin
A7S31_RS04130 (857269)	857269..857667	+	399	WP_000911337.1	tRNA(fMet)-specific endonuclease VapC	Toxin
A7S31_RS04135 (858474)	858474..859010	+	537	WP_001038500.1	STM3031 family outer membrane protein	-
A7S31_RS04140 (859057)	859057..859689	+	633	WP_001522936.1	YfdX family protein	-
A7S31_RS04145 (860408)	860408..860989	+	582	WP_001244651.1	fimbrial protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	856582..866812	10230

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15037.43 Da
• Isoelectric Point: 7.7785

>T203175 WP_000911337.1 NZ_CP075134:857269-857667 [Salmonella enterica subsp. enterica serovar Saintpaul]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Nucleotide

• Length: 399 bp

>T203175 NZ_CP099888:67960-68481 [Escherichia albertii]
GTGAGCAATACAACGATAGAGATTTTCTCTGGAGAGAAAGATTATGATCTAAACGGTTTTGATTGCGGCGAAGAGTCACT
AAACGCCTTTTTAGCCAACCACTTAAAAAGGCAGCATGAGGGAAAAATTCTTCGTGCTTATGTGCTTTGCACTCAAGAAG
AAAGGCCAAAAGTGTTAGGATATTACACTTTGTCAGGTAGTTGTTTTGAAAAGGAGTCCTTACCTTCAAGAAGCAAACAA
AAGAAGGTTCCTTATCGGAATGTTCCAAGTGTTACTTTGGGTAGGCTGGCTTTGGACAAGTCCCTTCAAGGTCAAGGATT
TGGCTCAATGCTTGTAACACATGCAATGCGCGTTGTGTACAATGCATCTCTTGCTGTAGGCATTCATGGACTTTTCGTTG
AGGCGTTAAATGACAAAGCCAAGGCGTTTTATAAAAGTTTAGGCTTTATCCAGCTGGTTGGTAACAACGAGCGTTCTTTG
TTCTATCCTACAAAATCTATCGAAAAATTGTTCGAAGAATAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8500.48 Da
• Isoelectric Point: 5.0053

>AT203175 WP_000557545.1 NZ_CP075134:857042-857269 [Salmonella enterica subsp. enterica serovar Saintpaul]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Nucleotide

• Length: 228 bp

>AT203175 NZ_CP099888:67683-67952 [Escherichia albertii]
ATGTCAGCACTAAAAAAGCAGCGCATCGATTTGAGATTAACCGATGACGATAAAAGCATCATCGAGGAAGCTGCCGCAAT
GTCTAACCAGAGCATTACTCAGTTTATGGTTAGCAGTGCATCTGAACGTGCCGTGAAAGTTATAGAGCAACACCGTAGAC
TAGTTCTGAATGAAGAATCCTGGAATCTGGTTATGGACGCTATAAGCAATCCTCCGGCACCGAACGACAAGCTGAAACGA
GCTGCTGATCGTCTGAAAAGCATGGAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A0R9MGW6