Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 211045..211805 Replicon chromosome
Accession NZ_CP075134
Organism Salmonella enterica subsp. enterica serovar Saintpaul strain CFSAN044909

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag A7S31_RS00990 Protein ID WP_000533909.1
Coordinates 211320..211805 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag A7S31_RS00985 Protein ID WP_000965886.1
Coordinates 211045..211332 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S31_RS00965 (206450) 206450..207361 + 912 WP_001168544.1 glycine--tRNA ligase subunit alpha -
A7S31_RS00970 (207371) 207371..209440 + 2070 WP_001522165.1 glycine--tRNA ligase subunit beta -
A7S31_RS23285 (209830) 209830..210228 + 399 Protein_194 IS3 family transposase -
A7S31_RS00980 (210400) 210400..210867 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
A7S31_RS00985 (211045) 211045..211332 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
A7S31_RS00990 (211320) 211320..211805 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
A7S31_RS00995 (212176) 212176..212715 - 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
A7S31_RS01000 (212878) 212878..213090 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
A7S31_RS01005 (213378) 213378..213668 - 291 WP_000455790.1 HTH-type transcriptional regulator -
A7S31_RS01010 (214107) 214107..214817 + 711 WP_000190524.1 DUF3053 domain-containing protein -
A7S31_RS01015 (214867) 214867..215841 - 975 WP_001522229.1 glyoxylate/hydroxypyruvate reductase GhrB -
A7S31_RS01020 (216060) 216060..216722 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T203172 WP_000533909.1 NZ_CP075134:211320-211805 [Salmonella enterica subsp. enterica serovar Saintpaul]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T203172 NZ_CP099887:3918186-3918338 [Escherichia albertii]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT203172 WP_000965886.1 NZ_CP075134:211045-211332 [Salmonella enterica subsp. enterica serovar Saintpaul]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT203172 NZ_CP099887:c3918137-3918080 [Escherichia albertii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References