Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4476596..4477377 Replicon chromosome
Accession NZ_CP075132
Organism Salmonella enterica subsp. enterica serovar Inverness strain CFSAN044911

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A752VN12
Locus tag A7S33_RS22125 Protein ID WP_000622305.1
Coordinates 4476596..4477087 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A3V4SIN7
Locus tag A7S33_RS22130 Protein ID WP_001110453.1
Coordinates 4477084..4477377 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S33_RS22085 (4471691) 4471691..4471777 + 87 Protein_4356 porin family protein -
A7S33_RS22090 (4471868) 4471868..4472620 + 753 WP_000842407.1 non-specific acid phosphatase -
A7S33_RS22095 (4472765) 4472765..4473613 - 849 WP_001627551.1 SdiA-regulated domain-containing protein -
A7S33_RS22100 (4473639) 4473639..4473800 - 162 WP_001816720.1 hypothetical protein -
A7S33_RS22105 (4474061) 4474061..4474237 - 177 WP_139782396.1 FaeA/PapI family transcriptional regulator -
A7S33_RS22110 (4474839) 4474839..4475042 - 204 Protein_4361 transcriptional regulator -
A7S33_RS22115 (4475631) 4475631..4475888 + 258 WP_001112996.1 hypothetical protein -
A7S33_RS22120 (4476133) 4476133..4476381 - 249 Protein_4363 IS481 family transposase -
A7S33_RS22125 (4476596) 4476596..4477087 - 492 WP_000622305.1 GNAT family N-acetyltransferase Toxin
A7S33_RS22130 (4477084) 4477084..4477377 - 294 WP_001110453.1 DUF1778 domain-containing protein Antitoxin
A7S33_RS25335 (4477695) 4477695..4477917 + 223 Protein_4366 hypothetical protein -
A7S33_RS22135 (4478181) 4478181..4479056 + 876 WP_000921676.1 AraC family transcriptional regulator -
A7S33_RS22140 (4479053) 4479053..4479340 + 288 WP_076018242.1 transcriptional regulator RtsB -
A7S33_RS25340 (4479333) 4479333..4479515 - 183 WP_001527266.1 ATP-binding cassette domain-containing protein -
A7S33_RS25345 (4479535) 4479535..4479634 + 100 Protein_4370 hypothetical protein -
A7S33_RS25350 (4479745) 4479745..4479879 + 135 Protein_4371 hypothetical protein -
A7S33_RS22150 (4480174) 4480174..4481079 - 906 WP_001268209.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(2-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17606.43 Da        Isoelectric Point: 7.7297

>T203169 WP_000622305.1 NZ_CP075132:c4477087-4476596 [Salmonella enterica subsp. enterica serovar Inverness]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T203169 NZ_CP099887:2416924-2417310 [Escherichia albertii]
ATGATTTGGGTCAGTGCACAGGAGGTCATTGCCTTCCACGATCGAATTTTGCAACGTTTTCCCGGTGTGGCGGGCCTGAC
TGACCCCGGCAGAGCACAGGCGTTGATTTATCGCGTGCAGAATCGTGTTCACTACGAGGGCGTTACTGACCTGTTTGAAC
TGGCAGCAACCTACTGGGTTGCCATCGCTCGCGGTCACATCTTTCATGATGGTAATAAACGTACCGCATTTTTCGTTACT
ATGACCTTTCTTTGGCGCAATGGCATCCGTATCCGTGACGTTGATAACTCGCTGGAGAACCTGACTGTCGAAGCGGCTAC
CGGAGAAAAAACGGTCGGTCAATTAGCGCGATGTTTACGTGAACGAGTGGATAGTTCCGGGAATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10948.57 Da        Isoelectric Point: 9.8590

>AT203169 WP_001110453.1 NZ_CP075132:c4477377-4477084 [Salmonella enterica subsp. enterica serovar Inverness]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT203169 NZ_CP099887:2416706-2416927 [Escherichia albertii]
ATGCAAACTTACACTTCCACACAAGCCAGAGCCAATATTGCCACTGTACTGGATACCGCGTTGAATGGTGAGCCAGTTGA
AATCACCCGTCGCGACGGCAGCTCTGCCGTGCTCATTAGTAAAGCCGCATTCGAGGCGTATCAAAATGCGAAACTGGACG
CGGAATTTGATGCCATCATGCAACGTCATGAACACACAATTGAAGCGTTGACTGATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A752VN12

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIN7

References