Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4346554..4347070 Replicon chromosome
Accession NZ_CP075132
Organism Salmonella enterica subsp. enterica serovar Inverness strain CFSAN044911

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag A7S33_RS21445 Protein ID WP_000220578.1
Coordinates 4346554..4346838 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag A7S33_RS21450 Protein ID WP_000212724.1
Coordinates 4346828..4347070 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S33_RS21430 (4341670) 4341670..4343322 + 1653 WP_023227796.1 alpha,alpha-phosphotrehalase -
A7S33_RS21435 (4343731) 4343731..4345869 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
A7S33_RS21440 (4346086) 4346086..4346550 + 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
A7S33_RS21445 (4346554) 4346554..4346838 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A7S33_RS21450 (4346828) 4346828..4347070 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
A7S33_RS21455 (4347148) 4347148..4349061 - 1914 WP_023227795.1 BglG family transcription antiterminator -
A7S33_RS21460 (4349078) 4349078..4349818 - 741 WP_000779252.1 KDGP aldolase family protein -
A7S33_RS21465 (4349815) 4349815..4350933 - 1119 WP_001139176.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
A7S33_RS21470 (4350917) 4350917..4352050 - 1134 WP_001627634.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T203168 WP_000220578.1 NZ_CP075132:c4346838-4346554 [Salmonella enterica subsp. enterica serovar Inverness]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T203168 NZ_CP099887:2117423-2117526 [Escherichia albertii]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAAAAC
AGGAATCGTTTTCGGTCTCTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT203168 WP_000212724.1 NZ_CP075132:c4347070-4346828 [Salmonella enterica subsp. enterica serovar Inverness]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT203168 NZ_CP099887:c2117528-2117296 [Escherichia albertii]
ATAAAAAGAGACCGAAAACGATTCCTGTTTTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTACAAAATGGTCAG
TAAAAAGCGCGTCGGCCATCGTCTTAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGTGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References