Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3655980..3656600 Replicon chromosome
Accession NZ_CP075132
Organism Salmonella enterica subsp. enterica serovar Inverness strain CFSAN044911

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag A7S33_RS18275 Protein ID WP_001280991.1
Coordinates 3656382..3656600 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag A7S33_RS18270 Protein ID WP_000344807.1
Coordinates 3655980..3656354 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S33_RS18260 (3651119) 3651119..3652312 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
A7S33_RS18265 (3652335) 3652335..3655484 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
A7S33_RS18270 (3655980) 3655980..3656354 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
A7S33_RS18275 (3656382) 3656382..3656600 + 219 WP_001280991.1 HHA domain-containing protein Toxin
A7S33_RS18280 (3656779) 3656779..3657330 + 552 WP_001278791.1 maltose O-acetyltransferase -
A7S33_RS18285 (3657448) 3657448..3657918 + 471 WP_000136183.1 YlaC family protein -
A7S33_RS18290 (3657974) 3657974..3658114 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
A7S33_RS18295 (3658120) 3658120..3658380 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
A7S33_RS18300 (3658605) 3658605..3660155 + 1551 WP_000213145.1 EAL domain-containing protein -
A7S33_RS18310 (3660386) 3660386..3660775 + 390 WP_000961285.1 MGMT family protein -
A7S33_RS18315 (3660808) 3660808..3661377 - 570 WP_000779801.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T203167 WP_001280991.1 NZ_CP075132:3656382-3656600 [Salmonella enterica subsp. enterica serovar Inverness]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T203167 NZ_CP099887:1093772-1093924 [Escherichia albertii]
ATGCTGACAAAATATGCCCTTGTGGCAATCATCGTACTGTGTTGTACAGTACTGGGATTCACGCTGATGGTAGGCGACTC
GTTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT203167 WP_000344807.1 NZ_CP075132:3655980-3656354 [Salmonella enterica subsp. enterica serovar Inverness]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT203167 NZ_CP099887:c1093727-1093679 [Escherichia albertii]
GTTCGAACGTAGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References