Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 2622121..2622935 | Replicon | chromosome |
| Accession | NZ_CP075132 | ||
| Organism | Salmonella enterica subsp. enterica serovar Inverness strain CFSAN044911 | ||
Toxin (Protein)
| Gene name | TacT3 | Uniprot ID | A0A8E6Q2X6 |
| Locus tag | A7S33_RS13130 | Protein ID | WP_023228035.1 |
| Coordinates | 2622408..2622935 (+) | Length | 176 a.a. |
Antitoxin (Protein)
| Gene name | TacA3 | Uniprot ID | M7S6I2 |
| Locus tag | A7S33_RS13125 | Protein ID | WP_000855694.1 |
| Coordinates | 2622121..2622411 (+) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A7S33_RS13095 (2618049) | 2618049..2618699 | - | 651 | WP_001674874.1 | type III secretion system transcriptional activator InvF | - |
| A7S33_RS13100 (2619156) | 2619156..2619599 | + | 444 | WP_000715096.1 | SPI-1 type III secretion system invasion lipoprotein InvH | - |
| A7S33_RS13105 (2620030) | 2620030..2620479 | + | 450 | WP_000381612.1 | membrane protein | - |
| A7S33_RS13110 (2620464) | 2620464..2620811 | + | 348 | WP_001669174.1 | DUF1493 family protein | - |
| A7S33_RS13115 (2621084) | 2621084..2621410 | - | 327 | WP_000393302.1 | hypothetical protein | - |
| A7S33_RS13120 (2621651) | 2621651..2621851 | + | 201 | Protein_2596 | transposase | - |
| A7S33_RS13125 (2622121) | 2622121..2622411 | + | 291 | WP_000855694.1 | DUF1778 domain-containing protein | Antitoxin |
| A7S33_RS13130 (2622408) | 2622408..2622935 | + | 528 | WP_023228035.1 | GNAT family N-acetyltransferase | Toxin |
| A7S33_RS13135 (2623008) | 2623008..2623417 | - | 410 | Protein_2599 | IS5/IS1182 family transposase | - |
| A7S33_RS13140 (2623650) | 2623650..2624306 | + | 657 | WP_000420452.1 | protein-serine/threonine phosphatase | - |
| A7S33_RS13145 (2624550) | 2624550..2625044 | - | 495 | WP_000424947.1 | hypothetical protein | - |
| A7S33_RS13150 (2625071) | 2625071..2625739 | - | 669 | WP_000445915.1 | hypothetical protein | - |
| A7S33_RS13155 (2625896) | 2625896..2626135 | - | 240 | Protein_2603 | hypothetical protein | - |
| A7S33_RS13160 (2626326) | 2626326..2626724 | - | 399 | Protein_2604 | cytoplasmic protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 2623008..2623148 | 140 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19038.89 Da Isoelectric Point: 9.6420
>T203165 WP_023228035.1 NZ_CP075132:2622408-2622935 [Salmonella enterica subsp. enterica serovar Inverness]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDPPLSLLL
SFKTLYAALSASGRL
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDPPLSLLL
SFKTLYAALSASGRL
Download Length: 528 bp
>T203165 NZ_CP099887:c812613-812236 [Escherichia albertii]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCACTACGGCCTCGCGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AAGCGGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACCGAACAGTAAATAACATTACTCTGGGTAAGCATCCGGAGGCGAAACAATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCACTACGGCCTCGCGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AAGCGGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACCGAACAGTAAATAACATTACTCTGGGTAAGCATCCGGAGGCGAAACAATGA
Antitoxin
Download Length: 97 a.a. Molecular weight: 10664.50 Da Isoelectric Point: 6.3133
>AT203165 WP_000855694.1 NZ_CP075132:2622121-2622411 [Salmonella enterica subsp. enterica serovar Inverness]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
Download Length: 291 bp
>AT203165 NZ_CP099887:c813071-812703 [Escherichia albertii]
GTGTCAGACACACTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTTGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACACACTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTTGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|