Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 202207..202967 Replicon chromosome
Accession NZ_CP075132
Organism Salmonella enterica subsp. enterica serovar Inverness strain CFSAN044911

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag A7S33_RS00945 Protein ID WP_000533909.1
Coordinates 202482..202967 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag A7S33_RS00940 Protein ID WP_000965886.1
Coordinates 202207..202494 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S33_RS00920 (197612) 197612..198523 + 912 WP_001168556.1 glycine--tRNA ligase subunit alpha -
A7S33_RS00925 (198533) 198533..200602 + 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
A7S33_RS25040 (200992) 200992..201390 + 399 Protein_184 IS3 family transposase -
A7S33_RS00935 (201562) 201562..202029 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
A7S33_RS00940 (202207) 202207..202494 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
A7S33_RS00945 (202482) 202482..202967 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
A7S33_RS00950 (203338) 203338..203877 - 540 WP_000047140.1 copper-binding periplasmic metallochaperone CueP -
A7S33_RS00955 (204052) 204052..204264 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
A7S33_RS00960 (204552) 204552..204842 - 291 WP_000455790.1 HTH-type transcriptional regulator -
A7S33_RS00965 (205281) 205281..205991 + 711 WP_000190524.1 DUF3053 domain-containing protein -
A7S33_RS00970 (206041) 206041..207015 - 975 WP_001522229.1 glyoxylate/hydroxypyruvate reductase GhrB -
A7S33_RS00975 (207234) 207234..207896 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T203153 WP_000533909.1 NZ_CP075132:202482-202967 [Salmonella enterica subsp. enterica serovar Inverness]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T203153 NZ_CP099886:3990550-3990936 [Escherichia albertii]
ATGATTTGGGTCAGTGCACAGGAGGTCATTGCCTTCCACGATCGAATTTTGCAACGTTTTCCCGGTGTGGCGGGCCTGAC
TGACCCCGGCAGAGCACAGGCGTTGATTTATCGCGTGCAGAATCGTGTTCACTACGAGGGCGTTACTGACCTGTTTGAAC
TGGCAGCAACCTACTGGGTTGCCATCGCTCGCGGTCACATCTTTCATGATGGTAATAAACGTACCGCATTTTTCGTTACT
ATGACCTTTCTTTGGCGCAATGGCATCCGTATCCGTGACGTTGATAACTCGCTGGAGAACCTGACTGTCGAAGCGGCTAC
CGGAGAAAAAACGGTCGGTCAATTAGCACGATGTTTACGTGAACGAGTGGATAGTTCCGGGAATTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT203153 WP_000965886.1 NZ_CP075132:202207-202494 [Salmonella enterica subsp. enterica serovar Inverness]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT203153 NZ_CP099886:3990332-3990553 [Escherichia albertii]
ATGCAAACTTACACTTCCACACAAGCCAGAGCCAATATTGCCACTGTACTGGATACCGCGTTGAATGGTGAGCCAGTTGA
AATCACCCGTCGCGACGGCAGCTCTGCCGTGCTCATTAGTAAAGCCGCATTCGAGGCGTATCAAAATGCGAAACTGGACG
CGGAATTTGATGCCATCATGCAACGTCATGAACACACAATTGAAGCGTTGACTGATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References