Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 33953..34596 Replicon plasmid pCFSAN044921_1
Accession NZ_CP075130
Organism Salmonella enterica subsp. enterica serovar Rubislaw strain CFSAN044921

Toxin (Protein)


Gene name vagD Uniprot ID A0A632GNP3
Locus tag A7S43_RS23735 Protein ID WP_001644958.1
Coordinates 34180..34596 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A5Z7X8E3
Locus tag A7S43_RS23730 Protein ID WP_001644959.1
Coordinates 33953..34183 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S43_RS23710 (A7S43_23700) 29319..29558 - 240 Protein_32 RNA 2'-phosphotransferase -
A7S43_RS23715 (A7S43_23705) 29879..32668 + 2790 WP_070801099.1 autotransporter outer membrane beta-barrel domain-containing protein -
A7S43_RS23720 (A7S43_23710) 32815..33204 + 390 Protein_34 IS3 family transposase -
A7S43_RS23725 (A7S43_23715) 33257..33520 - 264 WP_024153651.1 hypothetical protein -
A7S43_RS23730 (A7S43_23720) 33953..34183 + 231 WP_001644959.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
A7S43_RS23735 (A7S43_23725) 34180..34596 + 417 WP_001644958.1 type II toxin-antitoxin system VapC family toxin Toxin
A7S43_RS24720 34738..34938 - 201 Protein_38 Lrp/AsnC family transcriptional regulator -
A7S43_RS23740 (A7S43_23730) 34992..35687 - 696 WP_024153690.1 IS6 family transposase -
A7S43_RS23745 (A7S43_23735) 35823..36443 - 621 WP_001644950.1 recombinase family protein -
A7S43_RS23750 (A7S43_23740) 36691..37896 + 1206 WP_001644949.1 AAA family ATPase -
A7S43_RS23755 (A7S43_23745) 37896..38870 + 975 WP_001644948.1 ParB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - iroN / pilW / iroN 1..137164 137164
- flank IS/Tn - - 34992..35687 695


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15078.48 Da        Isoelectric Point: 9.1880

>T203151 WP_001644958.1 NZ_CP075130:34180-34596 [Salmonella enterica subsp. enterica serovar Rubislaw]
VNKTYMLDTNICSFIMREQPKAVIRRLEQAVLRNHRIVVSAITYAEMRFGAIGKKASPRHGQLVDAFCARLDAILPWDRA
AVDATVEVKAALTAAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPNLVLEDWVK

Download         Length: 417 bp

>T203151 NZ_CP099886:c3164468-3164250 [Escherichia albertii]
ATGTCCGATAAACCTTTAACAAAAACCGATTATTTGATGCGTCTGCGTCGTTGCCAGACAATTGACACACTGGAACGTGT
TATCGAGAAAAATAAATATGAATTATCAGATAATGAATTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTTGCAGAGC
TGACTATGAATAAGCTATATGACAAGATACCTTCCTCAGTGTGGAAATTCATTCGGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8706.80 Da        Isoelectric Point: 4.4692

>AT203151 WP_001644959.1 NZ_CP075130:33953-34183 [Salmonella enterica subsp. enterica serovar Rubislaw]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLEKADADFLVEREDVVSDEGRFNL

Download         Length: 231 bp

>AT203151 NZ_CP099886:c3164868-3164494 [Escherichia albertii]
ATGGATGAATACTCACCAAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGTAACCATGGCTGGGTAAATGACCCAACCTCGGCAATCAATCTACAGCTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAACAGATTGATGAATATCTG
GACGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAACCGATT
GTTCCGTTGCTTTGTTAACGCCACCAAAGCGAATCCTGCAAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A632GNP3

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z7X8E3

References