Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4244298..4244814 Replicon chromosome
Accession NZ_CP075129
Organism Salmonella enterica subsp. enterica serovar Rubislaw strain CFSAN044921

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag A7S43_RS20570 Protein ID WP_000220578.1
Coordinates 4244298..4244582 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag A7S43_RS20575 Protein ID WP_000212724.1
Coordinates 4244572..4244814 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S43_RS20555 (4239414) 4239414..4241066 + 1653 WP_000155035.1 alpha,alpha-phosphotrehalase -
A7S43_RS20560 (4241475) 4241475..4243613 + 2139 WP_000187815.1 anaerobic ribonucleoside-triphosphate reductase -
A7S43_RS20565 (4243830) 4243830..4244294 + 465 WP_001009178.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
A7S43_RS20570 (4244298) 4244298..4244582 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A7S43_RS20575 (4244572) 4244572..4244814 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
A7S43_RS20580 (4244892) 4244892..4246805 - 1914 WP_001212131.1 BglG family transcription antiterminator -
A7S43_RS20585 (4246822) 4246822..4247562 - 741 WP_000779263.1 KDGP aldolase family protein -
A7S43_RS20590 (4247559) 4247559..4248677 - 1119 WP_001139184.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
A7S43_RS20595 (4248661) 4248661..4249794 - 1134 WP_001636647.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T203147 WP_000220578.1 NZ_CP075129:c4244582-4244298 [Salmonella enterica subsp. enterica serovar Rubislaw]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T203147 NZ_CP099886:2468516-2468866 [Escherichia albertii]
ATGGTGAAGCGAAGTGAATTTGAACGGGGAGACATTATGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCGAGG
TGCTGGTCGACCTGTGCTTGTACTCTCCGTTCAAGCCTTTAATCAACTGGGGATGACGCTGGTAGCCCCCATTACTCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCGTTACGTTGTGAAGAAGGCGATGTGTGTGGCGTGGTGGTGGTG
AATCAGGTACGAATGATGGATTTAAATGCCCGGCAGGCAAAGCGTATTGGTCTGGCTTGCGACGAGGTGGTGGAAGAGGT
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT203147 WP_000212724.1 NZ_CP075129:c4244814-4244572 [Salmonella enterica subsp. enterica serovar Rubislaw]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT203147 NZ_CP099886:2468271-2468522 [Escherichia albertii]
ATGCGTATTACCATAAAAAAATGGGGAAACAGTGCAGGTATGGTCATTCCCAATATTGTGATGAAAGGGCTTAAATTACA
GCCAGGGCAGAGTCTTGAGGCACAGGTGAGAAATAATCAATTGATTCTGACACCCGTCTCTAAGCGTTACTCGCTTGATG
AACTGTTGGCGCAGTGTGACATGAATGCTCCAGAACTCAGCGAGCAGGATGTCTGGGGGACGTTGTCCCCTGCAGGTGAC
GAAATATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References