Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3552834..3553454 Replicon chromosome
Accession NZ_CP075129
Organism Salmonella enterica subsp. enterica serovar Rubislaw strain CFSAN044921

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag A7S43_RS17390 Protein ID WP_001280991.1
Coordinates 3553236..3553454 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag A7S43_RS17385 Protein ID WP_000344807.1
Coordinates 3552834..3553208 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S43_RS17375 (3547973) 3547973..3549166 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
A7S43_RS17380 (3549189) 3549189..3552338 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
A7S43_RS17385 (3552834) 3552834..3553208 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
A7S43_RS17390 (3553236) 3553236..3553454 + 219 WP_001280991.1 HHA domain-containing protein Toxin
A7S43_RS17395 (3553633) 3553633..3554184 + 552 WP_001278786.1 maltose O-acetyltransferase -
A7S43_RS17400 (3554301) 3554301..3554771 + 471 WP_000136183.1 YlaC family protein -
A7S43_RS17405 (3554826) 3554826..3554966 - 141 WP_070794274.1 type B 50S ribosomal protein L36 -
A7S43_RS17410 (3554972) 3554972..3555232 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
A7S43_RS17415 (3555457) 3555457..3557007 + 1551 WP_001642888.1 EAL domain-containing protein -
A7S43_RS17425 (3557238) 3557238..3557627 + 390 WP_000961285.1 MGMT family protein -
A7S43_RS17430 (3557660) 3557660..3558229 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T203146 WP_001280991.1 NZ_CP075129:3553236-3553454 [Salmonella enterica subsp. enterica serovar Rubislaw]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T203146 NZ_CP099886:2069217-2069591 [Escherichia albertii]
ATGGCAAAAAGAACTGCGCTTTTTGATACCAATATCCTTATTGATTTGTTCAGCGGACGAATTGAGTCAAAACAGGCACT
GGAGGCATGGCCCCTACAGAATGCGATTAGTCTGGTCACATGGATGGAGGTGCTGGTTGGCGCTAAAAAATACAATCAAG
AACATCGCACACAGATTGCAATGAGTGCGTTTAACGTTATTGGGATTTCGCAGGATATCGCGGAACGAAGCGTTGCTTTG
AGGCAAGAGTATAGAATGAAACTTCCAGATGCCATTATTCTGGCAACAGCACAGATTTATGGCTTTGAATTGGTAACGCG
AAATACGAGAGATTTTGCGGGAATAGCAGGTGTAATCACACCCTATCAACCGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT203146 WP_000344807.1 NZ_CP075129:3552834-3553208 [Salmonella enterica subsp. enterica serovar Rubislaw]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT203146 NZ_CP099886:2068975-2069217 [Escherichia albertii]
ATGAGCGCTATGGCAGGTATGGATATGGGCAGAATTTTACTCGATTTATCCGATGAGGTGATTAAGCGACTTGATGATCT
CAAAGTGCAGCGCAATCTTCCTCGCGCAGAGCTATTACGAGAAGCGGTAGCTCAATATCTGGAAAATCAATCGAAAACGA
CAATATTCAGTGCTCTTGGTATCTGGCAAGGGTGTGAGGAAGATGGTGTCGAATATCAGCGTAAGCTGCGTGAGGAATGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References