Detailed information of TA system TA203145

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2133813..2134451
• Replicon: chromosome
• Accession: NZ_CP075129
• Organism: Salmonella enterica subsp. enterica serovar Rubislaw strain CFSAN044921

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A5Z7XAU3
• Locus tag: A7S43_RS10245
• Protein ID: WP_072209095.1
• Coordinates: 2134269..2134451 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A5W1Z1L9
• Locus tag: A7S43_RS10240
• Protein ID: WP_058645062.1
• Coordinates: 2133813..2134226 (-)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7S43_RS10215 (2129179)	2129179..2129406	+	228	WP_058645057.1	hypothetical protein	-
A7S43_RS10220 (2129485)	2129485..2131434	+	1950	WP_070809061.1	replication endonuclease	-
A7S43_RS10225 (2131579)	2131579..2131860	+	282	WP_108451050.1	hypothetical protein	-
A7S43_RS10230 (2131883)	2131883..2133019	+	1137	WP_070809062.1	DUF968 domain-containing protein	-
A7S43_RS10235 (2133016)	2133016..2133669	+	654	WP_070804841.1	bacteriophage antitermination protein Q	-
A7S43_RS10240 (2133813)	2133813..2134226	-	414	WP_058645062.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
A7S43_RS10245 (2134269)	2134269..2134451	-	183	WP_072209095.1	type II toxin-antitoxin system HicA family toxin	Toxin
A7S43_RS10250 (2134837)	2134837..2135349	+	513	WP_000259586.1	DUF1440 domain-containing protein	-
A7S43_RS10255 (2136034)	2136034..2136390	+	357	WP_070809063.1	hypothetical protein	-
A7S43_RS10260 (2136418)	2136418..2136603	-	186	WP_070809064.1	hypothetical protein	-
A7S43_RS10265 (2136905)	2136905..2137123	+	219	WP_058645066.1	phage holin	-
A7S43_RS10270 (2137101)	2137101..2137640	+	540	WP_070809065.1	lysozyme	-
A7S43_RS10275 (2137741)	2137741..2138205	+	465	WP_070809066.1	lysis protein	-
A7S43_RS10280 (2138237)	2138237..2138527	-	291	WP_070809067.1	Bor family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2117179..2167230	50051

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6891.15 Da
• Isoelectric Point: 10.8877

>T203145 WP_072209095.1 NZ_CP075129:c2134451-2134269 [Salmonella enterica subsp. enterica serovar Rubislaw]
MKSSELIKLLESKGWTLERINGSHHHFSHPDFPVIITVPHPRKDIKPGTLNQILKKAKLK

Nucleotide

• Length: 183 bp

>T203145 NZ_CP099886:2066891-2067202 [Escherichia albertii]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15250.99 Da
• Isoelectric Point: 4.5174

>AT203145 WP_058645062.1 NZ_CP075129:c2134226-2133813 [Salmonella enterica subsp. enterica serovar Rubislaw]
MLYPAFIEVDKDGSASGWFPDVPGCIFAGSTIEETYADARSAICAHFEVLCDKGFDIPSPRSIEQHVAAEPDDYSNGRWL
YVDVNMDQFDGRAERINVTLPHRLLDRIDATVKQHPDYGSRSAFLAAAARNELQKSL

Nucleotide

• Length: 414 bp

>AT203145 NZ_CP099886:2067203-2067493 [Escherichia albertii]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Structures

Toxin

• AlphaFold DB: A0A5Z7XAU3

Antitoxin

• AlphaFold DB: A0A5W1Z1L9