Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 938119..938779 Replicon chromosome
Accession NZ_CP075129
Organism Salmonella enterica subsp. enterica serovar Rubislaw strain CFSAN044921

Toxin (Protein)


Gene name cptA Uniprot ID A0A3Y0E4E4
Locus tag A7S43_RS04515 Protein ID WP_000244757.1
Coordinates 938366..938779 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag A7S43_RS04510 Protein ID WP_000351186.1
Coordinates 938119..938385 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S43_RS04490 (934047) 934047..935480 - 1434 WP_001230152.1 6-phospho-beta-glucosidase BglA -
A7S43_RS04495 (935639) 935639..935950 + 312 WP_058344418.1 N(4)-acetylcytidine aminohydrolase -
A7S43_RS04500 (936114) 936114..936773 + 660 WP_000250289.1 hemolysin III family protein -
A7S43_RS04505 (936889) 936889..937869 - 981 WP_000874170.1 tRNA-modifying protein YgfZ -
A7S43_RS04510 (938119) 938119..938385 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
A7S43_RS04515 (938366) 938366..938779 + 414 WP_000244757.1 protein YgfX Toxin
A7S43_RS04520 (938832) 938832..939353 - 522 WP_001055885.1 flavodoxin FldB -
A7S43_RS04525 (939466) 939466..940362 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
A7S43_RS04530 (940386) 940386..941099 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
A7S43_RS04535 (941105) 941105..942838 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16282.29 Da        Isoelectric Point: 11.1741

>T203136 WP_000244757.1 NZ_CP075129:938366-938779 [Salmonella enterica subsp. enterica serovar Rubislaw]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISRQH

Download         Length: 414 bp

>T203136 NZ_CP099883:c4037120-4036593 [Escherichia albertii]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTTTGCGAGCGTATATCCTTTGCCGCAACACTC
CAGAACGTCAGGTCCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTCACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGATTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCATTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCTCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCATTGGTTGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACTAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT203136 WP_000351186.1 NZ_CP075129:938119-938385 [Salmonella enterica subsp. enterica serovar Rubislaw]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT203136 NZ_CP099883:c4037393-4037127 [Escherichia albertii]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAATCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGTTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Y0E4E4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References