Detailed information of TA system TA203133

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1(toxin)
• Location: 4993485..4994101
• Replicon: chromosome
• Accession: NZ_CP075128
• Organism: Salmonella enterica subsp. diarizonae serovar 60:r:enxz15 strain CFSAN044923

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A8E9YCX3
• Locus tag: A7S45_RS24035
• Protein ID: WP_023249114.1
• Coordinates: 4993485..4993859 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A8E9YHE9
• Locus tag: A7S45_RS24040
• Protein ID: WP_001523745.1
• Coordinates: 4993859..4994101 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7S45_RS24020 (4990987)	4990987..4991889	+	903	WP_070789960.1	formate dehydrogenase subunit beta	-
A7S45_RS24025 (4991886)	4991886..4992521	+	636	WP_000829028.1	formate dehydrogenase cytochrome b556 subunit	-
A7S45_RS24030 (4992518)	4992518..4993447	+	930	WP_023249115.1	formate dehydrogenase accessory protein FdhE	-
A7S45_RS24035 (4993485)	4993485..4993859	-	375	WP_023249114.1	type II toxin-antitoxin system VapC family toxin	Toxin
A7S45_RS24040 (4993859)	4993859..4994101	-	243	WP_001523745.1	CopG family transcriptional regulator	Antitoxin
A7S45_RS24045 (4994306)	4994306..4995232	+	927	Protein_4743	alpha/beta hydrolase	-
A7S45_RS24050 (4995318)	4995318..4995629	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
A7S45_RS24055 (4995626)	4995626..4996072	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
A7S45_RS24060 (4996087)	4996087..4997028	-	942	WP_024134888.1	fatty acid biosynthesis protein FabY	-
A7S45_RS24065 (4997073)	4997073..4997510	-	438	WP_023249111.1	D-aminoacyl-tRNA deacylase	-
A7S45_RS24070 (4997507)	4997507..4998379	-	873	WP_023249110.1	virulence factor BrkB family protein	-
A7S45_RS24075 (4998373)	4998373..4998972	-	600	WP_023249109.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-112)

Antitoxin

• Ribbon-helix-helix protein, CopG (13-47)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13836.12 Da
• Isoelectric Point: 8.0689

>T203133 WP_023249114.1 NZ_CP075128:c4993859-4993485 [Salmonella enterica subsp. diarizonae serovar 60:r:e,n,x,z15]
MVKGSALFDTNILIDLFSGRIEAKHALEAYPPQNAISLITWMEVMVGAKKYHQENRTRIALSAFNVIGVTQEIAERSVIV
RQEYGMKLPDAIILATAQVHRCELVTRNTKDFAGIPGVITPYHL

Nucleotide

• Length: 375 bp

>T203133 NZ_CP099883:c2411840-2411508 [Escherichia albertii]
ATGGACAGAGGAGAAATCTGGCTTGTTTCACTTGACCCTATCGCCGGGCATGAGCAAAGCGGAAAACGCCCGGTGCTTAT
CGTTTCTCCGGCCTCGTTTAACGAGGTCACCCGGTTGCCCGTCATTGTTCCGGTAACCAGCGGTGGGCAATTTGCCCGTA
GCGCGGGTTTTGCGGTTTCGCTGGAGGGCGCTGGCACAAAAACGACGGGGATTATTCGTTGCGATCAGCCCAGAACCATT
GATATGGGAGCCCGAAACGGTAAGCGGCTGGAGCGCATACCTGACGGTATCATCAACGAGGTGCTGGCAAGGCTGGAAAC
CATCCTGGCCTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9437.77 Da
• Isoelectric Point: 4.4463

>AT203133 WP_001523745.1 NZ_CP075128:c4994101-4993859 [Salmonella enterica subsp. diarizonae serovar 60:r:e,n,x,z15]
MMAGMDMGRILLDLSDDVIKRLDDLKVQRNLPRAELLREAVEQYLERQDRAETTISKALGLWQGCEEDGVEYQRKLREEW

Nucleotide

• Length: 243 bp

>AT203133 NZ_CP099883:c2412098-2411841 [Escherichia albertii]
ATGTATACCACACGTCTGAAAAAGGTTGGCGGTTCTGTCATGCTGGCTGTTCCGCCCGCCGTGCTGAAAACGCTGGCCCT
GTTGCCGGACAGCGAAGTCGGTGTAACCATCGACAACGGCTGCCTGATTATCGAACCGCAAAAACGACCACGCTATTCAC
TGGCCGAACTGCTGGCGCAATGCGATCCCCATGAAGAAATCAGTGATGAGGAGCGCGAATGGATTGATGCGCCTGCCGCA
GGGAAGGAGATCCTGTAA