Detailed information of TA system TA203132

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacT-ataR/DUF1778(antitoxin)
• Location: 4670316..4671073
• Replicon: chromosome
• Accession: NZ_CP075128
• Organism: Salmonella enterica subsp. diarizonae serovar 60:r:enxz15 strain CFSAN044923

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: A7S45_RS22710
• Protein ID: WP_023249556.1
• Coordinates: 4670591..4671073 (+)
• Length: 161 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: A0A5Y0S3F2
• Locus tag: A7S45_RS22705
• Protein ID: WP_001750501.1
• Coordinates: 4670316..4670600 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7S45_RS22690 (4666509)	4666509..4668197	-	1689	WP_070789718.1	PilN family type IVB pilus formation outer membrane protein	-
A7S45_RS22695 (4668218)	4668218..4668655	-	438	WP_023249558.1	type IV pilus biogenesis protein PilM	-
A7S45_RS22700 (4668655)	4668655..4669929	-	1275	WP_044136653.1	TcpQ domain-containing protein	-
A7S45_RS22705 (4670316)	4670316..4670600	+	285	WP_001750501.1	DUF1778 domain-containing protein	Antitoxin
A7S45_RS22710 (4670591)	4670591..4671073	+	483	WP_023249556.1	GNAT family N-acetyltransferase	Toxin
A7S45_RS22715 (4671352)	4671352..4671747	-	396	WP_023249555.1	glyoxalase/bleomycin resistance protein/dioxygenase	-
A7S45_RS22720 (4672014)	4672014..4672415	-	402	WP_023249554.1	HD domain-containing protein	-
A7S45_RS22725 (4672544)	4672544..4672711	-	168	WP_170245768.1	hypothetical protein	-
A7S45_RS22730 (4672636)	4672636..4673404	+	769	Protein_4491	IS3 family transposase	-
A7S45_RS22735 (4674440)	4674440..4675288	-	849	WP_024149777.1	SdiA-regulated domain-containing protein	-
A7S45_RS22740 (4675402)	4675402..4675659	-	258	WP_023249551.1	FaeA/PapI family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	4673174..4673302	128

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (30-149)

Antitoxin

• Vibrio phage ICP1, Orf50 (13-87)

Sequences

Toxin

Protein

• Length: 161 a.a.
• Molecular weight: 17947.68 Da
• Isoelectric Point: 6.8355

>T203132 WP_023249556.1 NZ_CP075128:4670591-4671073 [Salmonella enterica subsp. diarizonae serovar 60:r:e,n,x,z15]
MEINVTAPELLNEEHILQSFDCGNDVLSDWLCRRAMKNQHLNASRTFVICLECTKRVVGYYSIATGSISHVDLGRSLRQN
MPDPVPVVLLGRLAIDKCTQGQNFGKWLLNDAVTRVSNLADQVGIKAIMVHAIDEQAKAFYEYFGFVQSPVAPNTLFYKI

Nucleotide

• Length: 483 bp

>T203132 NZ_CP099883:c2229815-2229713 [Escherichia albertii]
GCAAGGCAACTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAAAACA
GGAATCGTTTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11033.58 Da
• Isoelectric Point: 8.5171

>AT203132 WP_001750501.1 NZ_CP075128:4670316-4670600 [Salmonella enterica subsp. diarizonae serovar 60:r:e,n,x,z15]
MQTTTRKSIRNKQINIRATDEERAVIDYAAKLVSKNRTDFIIEKAVNEAQNIILDQRVFVLDDARYQAFIEQLEAPVQNV
EGRQRLMDVKPEWK

Nucleotide

• Length: 285 bp

>AT203132 NZ_CP099883:2229711-2229943 [Escherichia albertii]
ATAAAAAGAGACCGAAAACGATTCCTGTTTTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTCAGTTGCCTTGCTCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTACAAAATGGTCAG
TAAAAAGCGCGTCGGCCATCGTCTTAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGTGGCGGTTTTTT

Structures

Antitoxin

• AlphaFold DB: A0A5Y0S3F2