Detailed information of TA system TA203131

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4344659..4345175
• Replicon: chromosome
• Accession: NZ_CP075128
• Organism: Salmonella enterica subsp. diarizonae serovar 60:r:enxz15 strain CFSAN044923

Toxin (Protein)

• Gene name: relE
• Uniprot ID: V1HEI0
• Locus tag: A7S45_RS20990
• Protein ID: WP_000220584.1
• Coordinates: 4344659..4344943 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V1HDU1
• Locus tag: A7S45_RS20995
• Protein ID: WP_023182636.1
• Coordinates: 4344933..4345175 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7S45_RS20975 (4339800)	4339800..4341452	+	1653	WP_023248623.1	alpha,alpha-phosphotrehalase	-
A7S45_RS20980 (4341862)	4341862..4344000	+	2139	WP_023248624.1	anaerobic ribonucleoside-triphosphate reductase	-
A7S45_RS20985 (4344185)	4344185..4344649	+	465	WP_023248625.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
A7S45_RS20990 (4344659)	4344659..4344943	-	285	WP_000220584.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A7S45_RS20995 (4344933)	4344933..4345175	-	243	WP_023182636.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
A7S45_RS21000 (4345254)	4345254..4347167	-	1914	WP_023248626.1	BglG family transcription antiterminator	-
A7S45_RS21005 (4347184)	4347184..4347924	-	741	WP_070790078.1	KDGP aldolase family protein	-
A7S45_RS21010 (4347921)	4347921..4349039	-	1119	WP_023248628.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
A7S45_RS21015 (4349023)	4349023..4350156	-	1134	WP_023248629.1	amidohydrolase/deacetylase family metallohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11085.02 Da
• Isoelectric Point: 10.3015

>T203131 WP_000220584.1 NZ_CP075128:c4344943-4344659 [Salmonella enterica subsp. diarizonae serovar 60:r:e,n,x,z15]
MTYELEFDPRALKEWQKLGETVKKQFRKKLVDVLSNPRVESARLRELPDCYKIKLKTSGYRLVYQVQDDVVLVVVIAIGK
REKSAVYRQADKRL

Nucleotide

• Length: 285 bp

>T203131 NZ_CP099883:c1949946-1949659 [Escherichia albertii]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9013.38 Da
• Isoelectric Point: 5.0651

>AT203131 WP_023182636.1 NZ_CP075128:c4345175-4344933 [Salmonella enterica subsp. diarizonae serovar 60:r:e,n,x,z15]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTVTISDSEDALLQTVRERLANPQKGIRVSLDDL

Nucleotide

• Length: 243 bp

>AT203131 NZ_CP099883:c1950185-1949946 [Escherichia albertii]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Structures

Toxin

• AlphaFold DB: A0A741MVA9