Detailed information of TA system TA203130

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): shpAB/BrnT-BrnA
• Location: 4204369..4204945
• Replicon: chromosome
• Accession: NZ_CP075128
• Organism: Salmonella enterica subsp. diarizonae serovar 60:r:enxz15 strain CFSAN044923

Toxin (Protein)

• Gene name: shpA
• Uniprot ID: A0A8E9YCK2
• Locus tag: A7S45_RS20310
• Protein ID: WP_023247536.1
• Coordinates: 4204658..4204945 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: A0A8E9YD15
• Locus tag: A7S45_RS20305
• Protein ID: WP_023247535.1
• Coordinates: 4204369..4204671 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7S45_RS20290 (4200879)	4200879..4203029	+	2151	WP_023247533.1	pyruvate/proton symporter BtsT	-
A7S45_RS20295 (4203124)	4203124..4203327	+	204	WP_000460616.1	YbdD/YjiX family protein	-
A7S45_RS20300 (4203338)	4203338..4204294	+	957	WP_053507632.1	GTPase	-
A7S45_RS20305 (4204369)	4204369..4204671	-	303	WP_023247535.1	BrnA antitoxin family protein	Antitoxin
A7S45_RS20310 (4204658)	4204658..4204945	-	288	WP_023247536.1	BrnT family toxin	Toxin
A7S45_RS20315 (4205214)	4205214..4206128	-	915	WP_023247537.1	restriction endonuclease	-
A7S45_RS20320 (4206326)	4206326..4209835	+	3510	WP_053529526.1	type I restriction-modification system endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (7-88)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (32-93)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11312.77 Da
• Isoelectric Point: 8.5288

>T203130 WP_023247536.1 NZ_CP075128:c4204945-4204658 [Salmonella enterica subsp. diarizonae serovar 60:r:e,n,x,z15]
MPMEFEWDANKAKSNLNKHGIRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGYEVIRIIS
TRKADRKERNRYEHG

Nucleotide

• Length: 288 bp

>T203130 NZ_CP099883:c1881666-1881280 [Escherichia albertii]
ATGATTTGGGTCAGTGCACAGGAGGTTATTGCCTTCCACGATCGAATTTTGCAACGTTTTCCCGGTGTGGCGGGCCTGAC
TGACCCCGGCAGAGCACAGGCGTTGATTTATCGCGTGCAGAATCGTGTTCACTACGAGGGCGTTACTGACCTGTTTGAAC
TGGCAGCAACCTACTGGGTTGCCATCGCTCGCGGTCACATCTTTCATGATGGTAATAAACGTACCGCATTTTTCGTTACT
ATGACCTTTCTTTGGCGCAATGGCATCCGTATCTGTGACGTTGATAACTCGCTGGAGAACCTGACTGTCGAAGCGGCTAC
CGGAGAAAAAACGGTCGGTCAATTAGCGCGATGTTTACGTGAACGAGTGGATAGTTCCGGGAATTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11397.04 Da
• Isoelectric Point: 10.3140

>AT203130 WP_023247535.1 NZ_CP075128:c4204671-4204369 [Salmonella enterica subsp. diarizonae serovar 60:r:e,n,x,z15]
MSMVKHKRGNVPALSAQHEAELKALAKKSDDEIDYSDIPASENGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Nucleotide

• Length: 303 bp

>AT203130 NZ_CP099883:c1881884-1881663 [Escherichia albertii]
ATGCAAACTTACACTTCCACACAAGCCAGAGCCAATATTGCCACTGTACTGGATACCGCGTTGAATGGTGAGCCAGTTGA
AATCACCCGTCGCGACGGCAGCTCTGCCGTGCTCATTAGTAAAGCCGCATTCGAGGCGTATCAAAATGCGAAACTGGACG
CGGAATTTGATGCCATCATGCAACGTCATGAACACACAATTGAAGCGTTGACTGATCGATGA