Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 3845170..3845769 Replicon chromosome
Accession NC_002570
Organism Bacillus halodurans C-125

Toxin (Protein)


Gene name mazF Uniprot ID Q9K6K8
Locus tag AYT26_RS18685 Protein ID WP_010899846.1
Coordinates 3845440..3845769 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A0M0KGU6
Locus tag AYT26_RS18680 Protein ID WP_041820955.1
Coordinates 3845170..3845439 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYT26_RS18665 3840557..3841180 - 624 WP_010899841.1 sugar transferase -
AYT26_RS18670 3841368..3842249 - 882 WP_010899842.1 UTP--glucose-1-phosphate uridylyltransferase GalU -
AYT26_RS18675 3842265..3844091 - 1827 WP_010899843.1 polysaccharide biosynthesis protein -
AYT26_RS18680 3845170..3845439 + 270 WP_041820955.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
AYT26_RS18685 3845440..3845769 + 330 WP_010899846.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
AYT26_RS21180 3846492..3846632 + 141 WP_010899847.1 hypothetical protein -
AYT26_RS18690 3846862..3847506 - 645 WP_010899848.1 bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase -
AYT26_RS18695 3847517..3848470 - 954 WP_010899849.1 sugar kinase -
AYT26_RS18700 3848537..3849292 - 756 WP_010899850.1 IclR family transcriptional regulator -
AYT26_RS18705 3849562..3850020 - 459 WP_010899851.1 NUDIX domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-107)

Antitoxin

SpoVT-AbrB domain

(16-61)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12139.93 Da        Isoelectric Point: 6.7069

>T20313 WP_010899846.1 NC_002570:3845440-3845769 [Bacillus halodurans C-125]
MPVPDRGNLVYVDFNPQSGHDQAGTRPAIVLSPKLFNKNTGFAVVCPITRQQKGYPFEIEIPPGLPIEGVILTDQVKSLD
WRARNFHIKGQAPEETVTDCLQLIHTFLS

Download         Length: 330 bp

>T20313 NC_002570:3845440-3845769 [Bacillus halodurans C-125]
ATGCCAGTACCGGATAGAGGGAATCTTGTTTATGTAGACTTTAACCCACAATCGGGTCATGACCAAGCCGGGACACGACC
GGCTATTGTTTTGTCCCCTAAATTATTTAATAAAAACACAGGTTTTGCGGTGGTTTGTCCAATTACCAGACAACAAAAAG
GTTATCCTTTTGAAATAGAAATACCACCGGGGTTACCTATTGAAGGGGTTATTCTTACTGACCAAGTAAAAAGTCTGGAT
TGGAGAGCAAGAAACTTTCACATTAAAGGACAAGCACCAGAGGAAACTGTTACTGATTGTTTACAACTTATTCATACATT
TTTATCTTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10048.56 Da        Isoelectric Point: 9.7279

>AT20313 WP_041820955.1 NC_002570:3845170-3845439 [Bacillus halodurans C-125]
MNVDENKGVTLMTTIQKWGNSLAVRIPNHYAKHINVTQGSEIELSLGSDQTIILKPKKRKPTLEELVAKITPENRHNEID
FGRTGKELL

Download         Length: 270 bp

>AT20313 NC_002570:3845170-3845439 [Bacillus halodurans C-125]
ATGAATGTAGATGAAAATAAAGGAGTGACACTCATGACTACTATACAAAAGTGGGGAAATAGTTTAGCTGTTCGTATTCC
GAACCATTATGCTAAACATATTAACGTTACGCAAGGATCTGAAATTGAACTAAGCTTAGGGAGTGATCAAACGATTATTT
TAAAGCCTAAAAAAAGAAAGCCAACATTAGAGGAATTAGTGGCAAAAATCACTCCTGAAAACAGACATAACGAAATTGAT
TTCGGGAGAACAGGAAAGGAATTGTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K6K8

Antitoxin

Source ID Structure
AlphaFold DB A0A0M0KGU6

References