Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3696813..3697433 Replicon chromosome
Accession NZ_CP075128
Organism Salmonella enterica subsp. diarizonae serovar 60:r:enxz15 strain CFSAN044923

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag A7S45_RS17890 Protein ID WP_001280991.1
Coordinates 3697215..3697433 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag A7S45_RS17885 Protein ID WP_000344807.1
Coordinates 3696813..3697187 (+) Length 125 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S45_RS17875 (3691950) 3691950..3693143 + 1194 WP_023246703.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
A7S45_RS17880 (3693166) 3693166..3696315 + 3150 WP_023246702.1 efflux RND transporter permease AcrB -
A7S45_RS17885 (3696813) 3696813..3697187 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
A7S45_RS17890 (3697215) 3697215..3697433 + 219 WP_001280991.1 HHA domain-containing protein Toxin
A7S45_RS17895 (3697613) 3697613..3698164 + 552 WP_053508533.1 maltose O-acetyltransferase -
A7S45_RS17900 (3698281) 3698281..3698751 + 471 WP_023246700.1 YlaC family protein -
A7S45_RS17905 (3698806) 3698806..3698946 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
A7S45_RS17910 (3698952) 3698952..3699212 - 261 WP_023182818.1 type B 50S ribosomal protein L31 -
A7S45_RS17915 (3699437) 3699437..3700987 + 1551 WP_023246699.1 EAL domain-containing protein -
A7S45_RS17925 (3701218) 3701218..3701607 + 390 WP_023246698.1 MGMT family protein -
A7S45_RS17930 (3701640) 3701640..3702209 - 570 WP_000779808.1 YbaY family lipoprotein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-69)

Antitoxin

(1-116)


Sequences


Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T203129 WP_001280991.1 NZ_CP075128:3697215-3697433 [Salmonella enterica subsp. diarizonae serovar 60:r:e,n,x,z15]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T203129 NZ_CP099883:c1859135-1858857 [Escherichia albertii]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCAAGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ACCCATTAAGCGGCGATCGCGATGGCATCTGGGCAATATCTGTATCAGGCAACTGGCGAATCACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT203129 WP_000344807.1 NZ_CP075128:3696813-3697187 [Salmonella enterica subsp. diarizonae serovar 60:r:e,n,x,z15]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT203129 NZ_CP099883:c1858857-1858573 [Escherichia albertii]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGACTGTTGACCGGAAAAGCGGCTTTGACGCCAGAAATGGCGA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCTGAG
AAAACGGTGGATGTGTCGCGGTTGCGCCGTCTGGTTGCGCAGTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4ICG


Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References