Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 3696813..3697433 | Replicon | chromosome |
Accession | NZ_CP075128 | ||
Organism | Salmonella enterica subsp. diarizonae serovar 60:r:enxz15 strain CFSAN044923 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | V1H8E6 |
Locus tag | A7S45_RS17890 | Protein ID | WP_001280991.1 |
Coordinates | 3697215..3697433 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | V1H4V6 |
Locus tag | A7S45_RS17885 | Protein ID | WP_000344807.1 |
Coordinates | 3696813..3697187 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
A7S45_RS17875 (3691950) | 3691950..3693143 | + | 1194 | WP_023246703.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
A7S45_RS17880 (3693166) | 3693166..3696315 | + | 3150 | WP_023246702.1 | efflux RND transporter permease AcrB | - |
A7S45_RS17885 (3696813) | 3696813..3697187 | + | 375 | WP_000344807.1 | Hha toxicity modulator TomB | Antitoxin |
A7S45_RS17890 (3697215) | 3697215..3697433 | + | 219 | WP_001280991.1 | HHA domain-containing protein | Toxin |
A7S45_RS17895 (3697613) | 3697613..3698164 | + | 552 | WP_053508533.1 | maltose O-acetyltransferase | - |
A7S45_RS17900 (3698281) | 3698281..3698751 | + | 471 | WP_023246700.1 | YlaC family protein | - |
A7S45_RS17905 (3698806) | 3698806..3698946 | - | 141 | WP_001197749.1 | type B 50S ribosomal protein L36 | - |
A7S45_RS17910 (3698952) | 3698952..3699212 | - | 261 | WP_023182818.1 | type B 50S ribosomal protein L31 | - |
A7S45_RS17915 (3699437) | 3699437..3700987 | + | 1551 | WP_023246699.1 | EAL domain-containing protein | - |
A7S45_RS17925 (3701218) | 3701218..3701607 | + | 390 | WP_023246698.1 | MGMT family protein | - |
A7S45_RS17930 (3701640) | 3701640..3702209 | - | 570 | WP_000779808.1 | YbaY family lipoprotein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8613.97 Da Isoelectric Point: 8.9008
>T203129 WP_001280991.1 NZ_CP075128:3697215-3697433 [Salmonella enterica subsp. diarizonae serovar 60:r:e,n,x,z15]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
Download Length: 219 bp
>T203129 NZ_CP099883:c1859135-1858857 [Escherichia albertii]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCAAGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ACCCATTAAGCGGCGATCGCGATGGCATCTGGGCAATATCTGTATCAGGCAACTGGCGAATCACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCAAGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ACCCATTAAGCGGCGATCGCGATGGCATCTGGGCAATATCTGTATCAGGCAACTGGCGAATCACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14453.27 Da Isoelectric Point: 5.1444
>AT203129 WP_000344807.1 NZ_CP075128:3696813-3697187 [Salmonella enterica subsp. diarizonae serovar 60:r:e,n,x,z15]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC
Download Length: 375 bp
>AT203129 NZ_CP099883:c1858857-1858573 [Escherichia albertii]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGACTGTTGACCGGAAAAGCGGCTTTGACGCCAGAAATGGCGA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCTGAG
AAAACGGTGGATGTGTCGCGGTTGCGCCGTCTGGTTGCGCAGTAG
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGACTGTTGACCGGAAAAGCGGCTTTGACGCCAGAAATGGCGA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCTGAG
AAAACGGTGGATGTGTCGCGGTTGCGCCGTCTGGTTGCGCAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|