Detailed information of TA system TA203128

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 3272938..3273585
• Replicon: chromosome
• Accession: NZ_CP075128
• Organism: Salmonella enterica subsp. diarizonae serovar 60:r:enxz15 strain CFSAN044923

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A8E9YA31
• Locus tag: A7S45_RS15780
• Protein ID: WP_023246826.1
• Coordinates: 3272938..3273120 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A8F0CEZ4
• Locus tag: A7S45_RS15785
• Protein ID: WP_023246827.1
• Coordinates: 3273151..3273585 (+)
• Length: 145 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7S45_RS15750 (3268660)	3268660..3269013	-	354	WP_023248686.1	DUF1353 domain-containing protein	-
A7S45_RS15755 (3269014)	3269014..3270036	-	1023	WP_023248687.1	hypothetical protein	-
A7S45_RS15760 (3270046)	3270046..3270279	-	234	WP_023247427.1	hypothetical protein	-
A7S45_RS15765 (3270348)	3270348..3270869	-	522	WP_070790296.1	hypothetical protein	-
A7S45_RS25200 (3270869)	3270869..3271114	-	246	WP_230316504.1	tail fiber domain-containing protein	-
A7S45_RS25205 (3271217)	3271217..3271606	-	390	Protein_3119	collagen-like protein	-
A7S45_RS15775 (3272537)	3272537..3272851	-	315	Protein_3120	prophage tail fiber N-terminal domain-containing protein	-
A7S45_RS15780 (3272938)	3272938..3273120	+	183	WP_023246826.1	type II toxin-antitoxin system HicA family toxin	Toxin
A7S45_RS15785 (3273151)	3273151..3273585	+	435	WP_023246827.1	hypothetical protein	Antitoxin
A7S45_RS15790 (3273608)	3273608..3274360	-	753	WP_070790279.1	hypothetical protein	-
A7S45_RS15795 (3274360)	3274360..3274716	-	357	WP_023246893.1	hypothetical protein	-
A7S45_RS15800 (3274726)	3274726..3277944	-	3219	WP_070795157.1	phage tail protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	cdtB	3256940..3314864	57924

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (20-82)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6932.12 Da
• Isoelectric Point: 11.0888

>T203128 WP_023246826.1 NZ_CP075128:3272938-3273120 [Salmonella enterica subsp. diarizonae serovar 60:r:e,n,x,z15]
MKYNEFRRWLIRQGAKFINAPGGGSHQRVILNGRESVFPYHGAKEIPEPLRKKILKDLGL

Nucleotide

• Length: 183 bp

>T203128 NZ_CP099883:1513931-1514086 [Escherichia albertii]
ATGAAGCAGCAAAAGGCGATGTTAGTCGCCCTGATCGTCATCTGTTTAACCGTCATTGTTACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Protein

• Length: 145 a.a.
• Molecular weight: 15663.04 Da
• Isoelectric Point: 5.1799

>AT203128 WP_023246827.1 NZ_CP075128:3273151-3273585 [Salmonella enterica subsp. diarizonae serovar 60:r:e,n,x,z15]
MFNYAVKLEHDPDTKSWIATCRDLPLFNSVGDSVDDALLESVDGAIVALSIEIDARRPIPAASQPEEGEYVIHLPVLVVM
KAALHNAMIATGTRKSDLARSMGMKGPQIDRLLDVCHSSKVETVELALQQLNRTVQISVNKVAA

Nucleotide

• Length: 435 bp

>AT203128 NZ_CP099883:c1513919-1513861 [Escherichia albertii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA