Detailed information of TA system TA203118

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-dnstrm_HI1420
• Location: 640770..641343
• Replicon: chromosome
• Accession: NZ_CP075128
• Organism: Salmonella enterica subsp. diarizonae serovar 60:r:enxz15 strain CFSAN044923

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: A0A8E9YDY4
• Locus tag: A7S45_RS03125
• Protein ID: WP_023246565.1
• Coordinates: 640770..641066 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: A7S45_RS03130
• Protein ID: WP_023246564.1
• Coordinates: 641068..641343 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7S45_RS03100 (636274)	636274..636570	+	297	WP_023246570.1	DUF4222 domain-containing protein	-
A7S45_RS03105 (636567)	636567..638717	+	2151	WP_023246569.1	DUF927 domain-containing protein	-
A7S45_RS03110 (639120)	639120..639575	+	456	WP_023246568.1	single-stranded DNA-binding protein	-
A7S45_RS03115 (639629)	639629..640228	+	600	WP_023246567.1	ProQ/FinO family protein	-
A7S45_RS03120 (640218)	640218..640430	+	213	WP_070788861.1	hypothetical protein	-
A7S45_RS03125 (640770)	640770..641066	+	297	WP_023246565.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A7S45_RS03130 (641068)	641068..641343	+	276	WP_023246564.1	putative addiction module antidote protein	Antitoxin
A7S45_RS03135 (641380)	641380..641718	+	339	WP_227005394.1	transcriptional regulator	-
A7S45_RS03140 (641801)	641801..641992	-	192	WP_024149539.1	hypothetical protein	-
A7S45_RS03145 (642236)	642236..642580	+	345	WP_023246561.1	single-stranded DNA-binding protein	-
A7S45_RS03150 (643062)	643062..643451	-	390	WP_070788863.1	hypothetical protein	-
A7S45_RS03155 (644376)	644376..644576	+	201	WP_077918424.1	hypothetical protein	-
A7S45_RS24935 (644699)	644699..645283	+	585	WP_070788864.1	FimD/PapC N-terminal domain-containing protein	-
A7S45_RS03165 (645465)	645465..645944	+	480	WP_070788865.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	rfaE	623251..698064	74813

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-92)

Antitoxin

• Cro/C1-type helix-turn-helix domain (45-89)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11083.88 Da
• Isoelectric Point: 10.3907

>T203118 WP_023246565.1 NZ_CP075128:640770-641066 [Salmonella enterica subsp. diarizonae serovar 60:r:e,n,x,z15]
MIDIKTTPEAEKWLKGLKDRVAKSKILIRIDRMRTGNFGDVEPVGGGLSELRIHHGKGYRVYFGNKNNEIILILCGGDKS
TQQDDIQKAKQIAKKWGF

Nucleotide

• Length: 297 bp

>T203118 NZ_CP099880:c4140995-4140654 [Escherichia albertii]
ATGAAAATTATTCCTGCAACGACGCTGCGGGCGACGACGTCATATCTGTCGCCCGTCGTGGTCTGGCAAACATTACTGGC
CCGCCTGCTGGAGCAGCACTACGGACTGAACCTTAATGACACACCATTCAACAATGAAAAGGTGATTCAGGAACACATAG
ACGCCGGGATCACTCTGGTTGATGCCGTCAATTTTCTGGTGGAGAAGTACGAATTGATCCGTATCGACAGGAAAGGATTT
AGCTGGCAGGAACAGACGCCTTATCTTCGTGCGGTCGATATTTTGCGGGCGAGGCAGGCTACAGGTCAGCTGCGTCGCTG
CCATAACACCACGGCACGGTGA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10035.38 Da
• Isoelectric Point: 4.7683

>AT203118 WP_023246564.1 NZ_CP075128:641068-641343 [Salmonella enterica subsp. diarizonae serovar 60:r:e,n,x,z15]
MKQVLKDFDVADYLEDEDDVIAYLNAVIAEGDNKQLFIALGNIARARNISRISKETGISREGIYKALSGDGNPSFNTLSK
ITKAMGLDLHF

Nucleotide

• Length: 276 bp

>AT203118 NZ_CP099880:c4141361-4141026 [Escherichia albertii]
ATGCTGCAAAAGGACAAGGTCATGCAACAAGAATGGGGGCTTCCCTGTACCGTTACACCACGCTTCACTGCACGACTGGT
ACAGGAAAGACATAACCTGCATTACCTGGCTGATCGGGCCGCAATCACCGGGAAATTCAGCTCCCCGGATCTGCTGCATA
TCGACCAGGCTTTTCCGGTGCTGATGAAACAACTGGAGCTGAAACTGGCTGACGGTGAACTCTCCCCCTGCCAACAACGT
ACCGTCACGCTATACGCCAAAGGACTAACCTGCGAAGCCGATACGCTGGGTTCCTGTGGTTACGTCTATATCGCTATTTA
TCCCACTCAACGCTGA