Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4558234..4558850 Replicon chromosome
Accession NZ_CP075127
Organism Salmonella enterica strain CFSAN044925

Toxin (Protein)


Gene name vapC Uniprot ID Q8Z2U3
Locus tag A7S47_RS21960 Protein ID WP_000238494.1
Coordinates 4558234..4558608 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8E9YHE9
Locus tag A7S47_RS21965 Protein ID WP_001523745.1
Coordinates 4558608..4558850 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S47_RS21945 (4555736) 4555736..4556638 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
A7S47_RS21950 (4556635) 4556635..4557270 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
A7S47_RS21955 (4557267) 4557267..4558196 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
A7S47_RS21960 (4558234) 4558234..4558608 - 375 WP_000238494.1 type II toxin-antitoxin system VapC family toxin Toxin
A7S47_RS21965 (4558608) 4558608..4558850 - 243 WP_001523745.1 CopG family transcriptional regulator Antitoxin
A7S47_RS21970 (4559055) 4559055..4559984 + 930 WP_001523720.1 alpha/beta hydrolase -
A7S47_RS21975 (4560070) 4560070..4560381 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
A7S47_RS21980 (4560378) 4560378..4560824 + 447 WP_001259012.1 type II toxin-antitoxin system HigA family antitoxin -
A7S47_RS21985 (4560839) 4560839..4561780 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
A7S47_RS21990 (4561825) 4561825..4562262 - 438 WP_000560956.1 D-aminoacyl-tRNA deacylase -
A7S47_RS21995 (4562259) 4562259..4563131 - 873 WP_001523799.1 virulence factor BrkB family protein -
A7S47_RS22000 (4563125) 4563125..4563724 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13908.18 Da        Isoelectric Point: 7.3567

>T203116 WP_000238494.1 NZ_CP075127:c4558608-4558234 [Salmonella enterica]
MVKGSALFDTNILIDLFSGRIEAKHALEAYPPQNAISLITWMEVMVGAKKYHQENRTRIALSAFNIIGVTQEIAERSVIV
RQEYGMKLPDAIILATAQVHRCELVTRNTKDFADIPGVITPYHL

Download         Length: 375 bp

>T203116 NZ_CP099880:4016428-4016580 [Escherichia albertii]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9437.77 Da        Isoelectric Point: 4.4463

>AT203116 WP_001523745.1 NZ_CP075127:c4558850-4558608 [Salmonella enterica]
MMAGMDMGRILLDLSDDVIKRLDDLKVQRNLPRAELLREAVEQYLERQDRAETTISKALGLWQGCEEDGVEYQRKLREEW

Download         Length: 243 bp

>AT203116 NZ_CP099880:c4016379-4016322 [Escherichia albertii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I6CND8

Antitoxin

Source ID Structure

References