Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4253781..4254562 Replicon chromosome
Accession NZ_CP075127
Organism Salmonella enterica strain CFSAN044925

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag A7S47_RS20650 Protein ID WP_000626100.1
Coordinates 4253781..4254272 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag A7S47_RS20655 Protein ID WP_001110452.1
Coordinates 4254269..4254562 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S47_RS20615 (4249776) 4249776..4250351 + 576 WP_001188509.1 transcriptional regulator -
A7S47_RS20625 (4250622) 4250622..4250699 - 78 Protein_4057 helix-turn-helix domain-containing protein -
A7S47_RS20630 (4250790) 4250790..4251122 - 333 WP_001165472.1 MerR family transcriptional regulator -
A7S47_RS20635 (4251194) 4251194..4251571 + 378 WP_000916345.1 EthD family reductase -
A7S47_RS20640 (4252604) 4252604..4252678 + 75 Protein_4060 porin family protein -
A7S47_RS20645 (4252781) 4252781..4253533 + 753 WP_001524265.1 non-specific acid phosphatase -
A7S47_RS20650 (4253781) 4253781..4254272 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
A7S47_RS20655 (4254269) 4254269..4254562 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
A7S47_RS20660 (4254879) 4254879..4255100 + 222 WP_001576552.1 hypothetical protein -
A7S47_RS20665 (4255365) 4255365..4256240 + 876 WP_000921674.1 AraC family transcriptional regulator -
A7S47_RS20670 (4256237) 4256237..4256524 + 288 WP_001269916.1 transcriptional regulator RtsB -
A7S47_RS20675 (4256664) 4256664..4256912 + 249 Protein_4067 Ig-like domain-containing protein -
A7S47_RS23195 (4257024) 4257024..4257155 + 132 Protein_4068 hypothetical protein -
A7S47_RS20680 (4257450) 4257450..4258355 - 906 WP_043985912.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T203115 WP_000626100.1 NZ_CP075127:c4254272-4253781 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T203115 NZ_CP099880:c3715443-3715102 [Escherichia albertii]
ATGTGGGACGTCGAGACAACGGAGACTTTCGACAACTGGTTTGATGCCCAGACTGTTGCGCTGAAAGAAGATTTGCTTGC
TGCAATGCTGATTCTTGCAGAGTATGGCCCACAGTTGGGCAGGCCCTTTGCGGACACGGTTAATGATTCACAGTTTTCAA
ATATGAAAGAATTACGCGTCCAACATCAGGGAAACCCGGTACGTGCTTTTTTTGCTTTCGATCCTGCGCGCCGTGGCATT
GTATTATGTGCAGGTGATAAAACGGGGTTAAATGAGAAAAAGTTTTATCGCGATATGATCAAGCTCGCTGATTCTGAATA
CCGTAATCATCTGAAAAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT203115 WP_001110452.1 NZ_CP075127:c4254562-4254269 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT203115 NZ_CP099880:c3715092-3714793 [Escherichia albertii]
ATGGCTACTCTAAAAGAACTGATGGCAAAGCAAAGCCCTGAAAGCCAGGCGCGTATTGCGGCAAAAGTTGAGGAAATGCG
CCAGACCATCGCCTTGCATCAGCTGAGAGAAGAACTCAATATTTCGCAAACGGAAATGGCGGCAGCGATGGGCATTAAGC
AACCGACCCTTGCAAAAATGGAGCAGGCAGATAACGATCCTCGGTTGTCTACGCTAAAACGCTATGTCGCGGCTTTAGGT
GGGGAATTGAGTATCGACGTTAAACTGCCTAATGGTAAGAGAGTTGCATTTCAGATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References