Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4122088..4122604 Replicon chromosome
Accession NZ_CP075127
Organism Salmonella enterica strain CFSAN044925

Toxin (Protein)


Gene name relE Uniprot ID A0A3U8PDE0
Locus tag A7S47_RS19980 Protein ID WP_000220575.1
Coordinates 4122088..4122372 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag A7S47_RS19985 Protein ID WP_000212724.1
Coordinates 4122362..4122604 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S47_RS19965 (4117204) 4117204..4118856 + 1653 WP_001523643.1 alpha,alpha-phosphotrehalase -
A7S47_RS19970 (4119265) 4119265..4121403 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
A7S47_RS19975 (4121620) 4121620..4122084 + 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
A7S47_RS19980 (4122088) 4122088..4122372 - 285 WP_000220575.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A7S47_RS19985 (4122362) 4122362..4122604 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
A7S47_RS19990 (4122682) 4122682..4124595 - 1914 WP_001523608.1 BglG family transcription antiterminator -
A7S47_RS19995 (4124612) 4124612..4125352 - 741 WP_001523583.1 KDGP aldolase family protein -
A7S47_RS20000 (4125349) 4125349..4126467 - 1119 WP_001523624.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
A7S47_RS20005 (4126451) 4126451..4127584 - 1134 WP_001523591.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10868.70 Da        Isoelectric Point: 10.0482

>T203114 WP_000220575.1 NZ_CP075127:c4122372-4122088 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQIKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T203114 NZ_CP099880:3543180-3543398 [Escherichia albertii]
ATGTCCGATAAACCTTTAACAAAAACCGATTATTTGATGCGTCTGCGTCGTTGCCAGACAATTGACACACTGGAACGTGT
TATCGAGAAAAATAAATATGAATTATCAGATAATGAATTGGCGGTATTTTACTCAGCTGCCGACCATCGGCTTGCAGAGC
TGACTATGAATAAGCTATATGACAAGATCCCTTCCTCAGTGTGGAAATTCATTCGGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT203114 WP_000212724.1 NZ_CP075127:c4122604-4122362 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT203114 NZ_CP099880:3542780-3543154 [Escherichia albertii]
ATGGATGAATACTCACCAAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGTAACCATGGCTGGGTAAATGACCCAACCTCGGCAATCAATCTACAGCTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAACAGATTGATGAATATCTG
GACGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAACCGATT
GTTCCGTTGCTTTGTTAACGCCACCAAAGCGAATCCTGCAAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3U8PDE0

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References