Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 846123..846783 Replicon chromosome
Accession NZ_CP075127
Organism Salmonella enterica strain CFSAN044925

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag A7S47_RS04065 Protein ID WP_000244756.1
Coordinates 846370..846783 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag A7S47_RS04060 Protein ID WP_000351186.1
Coordinates 846123..846389 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S47_RS04040 (842052) 842052..843485 - 1434 WP_058671920.1 6-phospho-beta-glucosidase BglA -
A7S47_RS04045 (843643) 843643..843954 + 312 WP_001522852.1 N(4)-acetylcytidine aminohydrolase -
A7S47_RS04050 (844118) 844118..844777 + 660 WP_000250289.1 hemolysin III family protein -
A7S47_RS04055 (844893) 844893..845873 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
A7S47_RS04060 (846123) 846123..846389 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
A7S47_RS04065 (846370) 846370..846783 + 414 WP_000244756.1 protein YgfX Toxin
A7S47_RS04070 (846836) 846836..847357 - 522 WP_001055885.1 flavodoxin FldB -
A7S47_RS04075 (847470) 847470..848366 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
A7S47_RS04080 (848390) 848390..849103 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
A7S47_RS04085 (849109) 849109..850842 + 1734 WP_001522853.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T203098 WP_000244756.1 NZ_CP075127:846370-846783 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T203098 NZ_CP099877:3917519-3917671 [Escherichia albertii]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT203098 WP_000351186.1 NZ_CP075127:846123-846389 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT203098 NZ_CP099877:c3917470-3917413 [Escherichia albertii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References