Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 37802..38445 Replicon plasmid pCFSAN044945
Accession NZ_CP075126
Organism Salmonella enterica strain CFSAN044945

Toxin (Protein)


Gene name vagD Uniprot ID A0A632GNP3
Locus tag A7S67_RS23800 Protein ID WP_001644958.1
Coordinates 38029..38445 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A5Z7X8E3
Locus tag A7S67_RS23795 Protein ID WP_001644959.1
Coordinates 37802..38032 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S67_RS23775 (A7S67_023770) 33147..33386 - 240 Protein_38 RNA 2'-phosphotransferase -
A7S67_RS23780 (A7S67_023775) 33707..36517 + 2811 WP_070812003.1 autotransporter outer membrane beta-barrel domain-containing protein -
A7S67_RS23785 (A7S67_023780) 36664..37053 + 390 Protein_40 IS3 family transposase -
A7S67_RS23790 (A7S67_023785) 37106..37369 - 264 WP_024153651.1 hypothetical protein -
A7S67_RS23795 (A7S67_023790) 37802..38032 + 231 WP_001644959.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
A7S67_RS23800 (A7S67_023795) 38029..38445 + 417 WP_001644958.1 type II toxin-antitoxin system VapC family toxin Toxin
A7S67_RS24600 38587..38787 - 201 Protein_44 Lrp/AsnC family transcriptional regulator -
A7S67_RS23805 (A7S67_023800) 38841..39536 - 696 WP_024153690.1 IS6 family transposase -
A7S67_RS23810 (A7S67_023805) 39672..40292 - 621 WP_001644950.1 recombinase family protein -
A7S67_RS23815 (A7S67_023810) 40540..41745 + 1206 WP_001644949.1 AAA family ATPase -
A7S67_RS23820 (A7S67_023815) 41745..42719 + 975 WP_001644948.1 ParB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - iroN / pilW / iroN 1..136500 136500
- flank IS/Tn - - 38841..39536 695


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15078.48 Da        Isoelectric Point: 9.1880

>T203095 WP_001644958.1 NZ_CP075126:38029-38445 [Salmonella enterica]
VNKTYMLDTNICSFIMREQPKAVIRRLEQAVLRNHRIVVSAITYAEMRFGAIGKKASPRHGQLVDAFCARLDAILPWDRA
AVDATVEVKAALTAAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPNLVLEDWVK

Download         Length: 417 bp

>T203095 NZ_CP099877:2416513-2416899 [Escherichia albertii]
ATGATTTGGGTCAGTGCACAGGAGGTCATTGCCTTCCACGATCGAATTTTGCAACGTTTTCCCGGTGTGGCGGGCCTGAC
TGACCCCGGCAGAGCACAGGCGTTGATTTATCGCGTGCAGAATCGTGTTCACTACGAGGGCGTTACTGACCTGTTTGAAC
TGGCAGCAACCTACTGGGTTGCCATCGCTCGCGGTCACATCTTTCATGATGGTAATAAACGTACCGCATTTTTCGTTACT
ATGACCTTTCTTTGGCGCAATGGCATCCGTATCCGTGACGTTGATAACTCGCTGGAGAACCTGACTGTCGAAGCGGCTAC
CGGAGAAAAAACGGTCGGTCAATTAGCGCGATGTTTACGTGAACGAGTGGATAGTTCCGGGAATTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8706.80 Da        Isoelectric Point: 4.4692

>AT203095 WP_001644959.1 NZ_CP075126:37802-38032 [Salmonella enterica]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLEKADADFLVEREDVVSDEGRFNL

Download         Length: 231 bp

>AT203095 NZ_CP099877:2416295-2416516 [Escherichia albertii]
ATGCAAACTTACACTTCCACACAAGCCAGAGCCAATATTGCCACTGTACTGGATACCGCGTTGAATGGTGAGCCAGTTGA
AATCACCCGTCGCGACGGCAGCTCTGCCGTGCTCATTAGTAAAGCCGCATTCGAGGCGTATCAAAATGCGAAACTGGACG
CGGAATTTGATGCCATCATGCAACGTCATGAACACACAATTGAAGCGTTGACTGATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A632GNP3

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z7X8E3

References