Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4392771..4393552 Replicon chromosome
Accession NZ_CP075125
Organism Salmonella enterica strain CFSAN044945

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A0R9NZI3
Locus tag A7S67_RS21430 Protein ID WP_000625912.1
Coordinates 4392771..4393262 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID M7RNV8
Locus tag A7S67_RS21435 Protein ID WP_001110450.1
Coordinates 4393259..4393552 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S67_RS21395 (4388182) 4388182..4388529 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
A7S67_RS21400 (4388505) 4388505..4390208 + 1704 WP_000068889.1 protein-disulfide reductase DsbD -
A7S67_RS21405 (4390245) 4390245..4390820 + 576 WP_001188509.1 transcriptional regulator -
A7S67_RS21415 (4391091) 4391091..4391165 - 75 Protein_4222 helix-turn-helix domain-containing protein -
A7S67_RS21420 (4391545) 4391545..4391622 + 78 Protein_4223 porin family protein -
A7S67_RS21425 (4391722) 4391722..4392474 + 753 WP_070794150.1 non-specific acid phosphatase -
A7S67_RS21430 (4392771) 4392771..4393262 - 492 WP_000625912.1 GNAT family N-acetyltransferase Toxin
A7S67_RS21435 (4393259) 4393259..4393552 - 294 WP_001110450.1 DUF1778 domain-containing protein Antitoxin
A7S67_RS24535 (4393869) 4393869..4394078 + 210 Protein_4227 hypothetical protein -
A7S67_RS21440 (4394342) 4394342..4395217 + 876 WP_000921676.1 AraC family transcriptional regulator -
A7S67_RS21445 (4395214) 4395214..4395501 + 288 WP_001269916.1 transcriptional regulator RtsB -
A7S67_RS24540 (4395494) 4395494..4395676 - 183 WP_001527266.1 ATP-binding cassette domain-containing protein -
A7S67_RS24545 (4395696) 4395696..4395795 + 100 Protein_4231 hypothetical protein -
A7S67_RS24550 (4395905) 4395905..4396039 + 135 Protein_4232 hypothetical protein -
A7S67_RS21455 (4396334) 4396334..4397239 - 906 WP_001268209.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17606.43 Da        Isoelectric Point: 7.7297

>T203092 WP_000625912.1 NZ_CP075125:c4393262-4392771 [Salmonella enterica]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T203092 NZ_CP099877:930406-930810 [Escherichia albertii]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTCTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGCTATTTTACTCATGCCCTGGCCGCTAAGTTATACCCCGTTATGGATGGTGTTGCTTTCGCTGGTGGTGTTTGATTGCG
TCCGCAGTCAGCGGCGCATTAATGCTCGTCAGGGGGAGATTCGCCTGTTGATGGATGGGCGTTTACGCTGGCAGGGGCAG
GAGTGGAGCATCGTCAGAGCGCCGTGGATGATTAAAACTGGCATGATGTTGCGTTTACTCTCTGATAGCGGCAAACGTCA
GCACCTGTGGCTGGCAGCCGACAGTATGGATGAAGCTGAATGGCGGGATTTGCGGCGAATTTTGTTACAACAAGAGATAC
AGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10949.56 Da        Isoelectric Point: 8.6141

>AT203092 WP_001110450.1 NZ_CP075125:c4393552-4393259 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT203092 NZ_CP099877:930159-930425 [Escherichia albertii]
ATGGACATTAACAATAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGATAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGACTGCTGGAATGTGACGATCCCGATT
TATTCAACTGGTTGATGAATCACGGTAAACCGGCCGACGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NZI3

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9PGG6

References