Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4252407..4252923 Replicon chromosome
Accession NZ_CP075125
Organism Salmonella enterica strain CFSAN044945

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag A7S67_RS20610 Protein ID WP_000220578.1
Coordinates 4252407..4252691 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag A7S67_RS20615 Protein ID WP_000212724.1
Coordinates 4252681..4252923 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S67_RS20595 (4247523) 4247523..4249175 + 1653 WP_000155035.1 alpha,alpha-phosphotrehalase -
A7S67_RS20600 (4249584) 4249584..4251722 + 2139 WP_000187815.1 anaerobic ribonucleoside-triphosphate reductase -
A7S67_RS20605 (4251939) 4251939..4252403 + 465 WP_001009178.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
A7S67_RS20610 (4252407) 4252407..4252691 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A7S67_RS20615 (4252681) 4252681..4252923 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
A7S67_RS20620 (4253001) 4253001..4254914 - 1914 WP_001212131.1 BglG family transcription antiterminator -
A7S67_RS20625 (4254931) 4254931..4255671 - 741 WP_000779263.1 KDGP aldolase family protein -
A7S67_RS20630 (4255668) 4255668..4256786 - 1119 WP_001139184.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
A7S67_RS20635 (4256770) 4256770..4257903 - 1134 WP_001636647.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T203091 WP_000220578.1 NZ_CP075125:c4252691-4252407 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T203091 NZ_CP099877:c812615-812238 [Escherichia albertii]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCACTACGGCCTCGCGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AAGCGGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACCGAACAGTAAATAACATTACTCTGGGTAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT203091 WP_000212724.1 NZ_CP075125:c4252923-4252681 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT203091 NZ_CP099877:c813073-812705 [Escherichia albertii]
GTGTCAGACACACTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTTGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References