Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3560995..3561615 Replicon chromosome
Accession NZ_CP075125
Organism Salmonella enterica strain CFSAN044945

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag A7S67_RS17435 Protein ID WP_001280991.1
Coordinates 3561397..3561615 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag A7S67_RS17430 Protein ID WP_000344807.1
Coordinates 3560995..3561369 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S67_RS17420 (3556134) 3556134..3557327 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
A7S67_RS17425 (3557350) 3557350..3560499 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
A7S67_RS17430 (3560995) 3560995..3561369 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
A7S67_RS17435 (3561397) 3561397..3561615 + 219 WP_001280991.1 HHA domain-containing protein Toxin
A7S67_RS17440 (3561794) 3561794..3562345 + 552 WP_001278786.1 maltose O-acetyltransferase -
A7S67_RS17445 (3562462) 3562462..3562932 + 471 WP_000136183.1 YlaC family protein -
A7S67_RS17450 (3562987) 3562987..3563127 - 141 WP_070794274.1 type B 50S ribosomal protein L36 -
A7S67_RS17455 (3563133) 3563133..3563393 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
A7S67_RS17460 (3563618) 3563618..3565168 + 1551 WP_001642888.1 EAL domain-containing protein -
A7S67_RS17470 (3565399) 3565399..3565788 + 390 WP_000961285.1 MGMT family protein -
A7S67_RS17475 (3565821) 3565821..3566390 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T203090 WP_001280991.1 NZ_CP075125:3561397-3561615 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T203090 NZ_CP099877:635399-635713 [Escherichia albertii]
ATGCACCTGATCACTCAAAAAGCATTGAAAGATGCAGCGGAAAAATATCCGCAGCATAAAACGGAGTTGGTGGCACTGGG
GAACACGATTGCTAAGGGATACTTCAAAAAACCTGAGTCATTAAAAGCAGTGTTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCACAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT203090 WP_000344807.1 NZ_CP075125:3560995-3561369 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT203090 NZ_CP099877:635710-636126 [Escherichia albertii]
ATGATTGCGATTGCCGATATCTTGCAAGCAGGAGAAAAGCTAACCGATGTGGCACCTTTTCTGGCGGGTATCCAGAGCGA
AGAACAGTATGCCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAATCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCTGAATTTAATGCGATGGTTCAAGCCATGCCTGGCGGT
GTTGCTGTGATTCGTACCCTGATGGATCAATACGGCTTAACCCTTTCCGATCTTCCAGAAATTGGCAGTAAATCCATGGT
GTCACGCGTTTTGAACGGGAAGAGAAAATTAACGCTGGAACACGCTAAAAAACTGGCAGCGCGATTCGGCATTTCCCCTG
CGTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References