Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2178967..2179605 Replicon chromosome
Accession NZ_CP075125
Organism Salmonella enterica strain CFSAN044945

Toxin (Protein)


Gene name hicA Uniprot ID A0A5Z7XAU3
Locus tag A7S67_RS10550 Protein ID WP_072209095.1
Coordinates 2179423..2179605 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A5W1Z1L9
Locus tag A7S67_RS10545 Protein ID WP_058645062.1
Coordinates 2178967..2179380 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S67_RS10520 (2174333) 2174333..2174560 + 228 WP_058645057.1 hypothetical protein -
A7S67_RS10525 (2174639) 2174639..2176588 + 1950 WP_070809061.1 replication endonuclease -
A7S67_RS10530 (2176733) 2176733..2177014 + 282 WP_108451050.1 hypothetical protein -
A7S67_RS10535 (2177037) 2177037..2178173 + 1137 WP_070809062.1 DUF968 domain-containing protein -
A7S67_RS10540 (2178170) 2178170..2178823 + 654 WP_070804841.1 bacteriophage antitermination protein Q -
A7S67_RS10545 (2178967) 2178967..2179380 - 414 WP_058645062.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
A7S67_RS10550 (2179423) 2179423..2179605 - 183 WP_072209095.1 type II toxin-antitoxin system HicA family toxin Toxin
A7S67_RS10555 (2179991) 2179991..2180503 + 513 WP_000259586.1 DUF1440 domain-containing protein -
A7S67_RS10560 (2181189) 2181189..2181545 + 357 WP_070809063.1 hypothetical protein -
A7S67_RS10565 (2181573) 2181573..2181758 - 186 WP_070809064.1 hypothetical protein -
A7S67_RS10570 (2182060) 2182060..2182278 + 219 WP_058645066.1 phage holin -
A7S67_RS10575 (2182256) 2182256..2182795 + 540 WP_070809065.1 lysozyme -
A7S67_RS10580 (2182896) 2182896..2183360 + 465 WP_070809066.1 lysis protein -
A7S67_RS10585 (2183392) 2183392..2183682 - 291 WP_070809067.1 Bor family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2162333..2219077 56744


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6891.15 Da        Isoelectric Point: 10.8877

>T203089 WP_072209095.1 NZ_CP075125:c2179605-2179423 [Salmonella enterica]
MKSSELIKLLESKGWTLERINGSHHHFSHPDFPVIITVPHPRKDIKPGTLNQILKKAKLK

Download         Length: 183 bp

>T203089 NZ_CP099877:c594181-593717 [Escherichia albertii]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAACCCATCATCATCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGCGCTGGTCGTTATCGTCTCTTCTTTCGTTACAGCGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACACTGCGCACCTACGGTAAAAAAACAGATGCCTATACAGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCAAGAGACAGAAGAAAAGCATTGA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15250.99 Da        Isoelectric Point: 4.5174

>AT203089 WP_058645062.1 NZ_CP075125:c2179380-2178967 [Salmonella enterica]
MLYPAFIEVDKDGSASGWFPDVPGCIFAGSTIEETYADARSAICAHFEVLCDKGFDIPSPRSIEQHVAAEPDDYSNGRWL
YVDVNMDQFDGRAERINVTLPHRLLDRIDATVKQHPDYGSRSAFLAAAARNELQKSL

Download         Length: 414 bp

>AT203089 NZ_CP099877:c594516-594181 [Escherichia albertii]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCTGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Z7XAU3

Antitoxin

Source ID Structure
AlphaFold DB A0A5W1Z1L9

References