Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 1312368..1313013 Replicon chromosome
Accession NZ_CP075125
Organism Salmonella enterica strain CFSAN044945

Toxin (Protein)


Gene name hicA Uniprot ID A0A5Z7XAV3
Locus tag A7S67_RS06325 Protein ID WP_070800844.1
Coordinates 1312831..1313013 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A5Z7XCZ9
Locus tag A7S67_RS06320 Protein ID WP_058645148.1
Coordinates 1312368..1312802 (-) Length 145 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S67_RS06305 (1307468) 1307468..1308211 + 744 WP_109183989.1 C40 family peptidase -
A7S67_RS06310 (1308109) 1308109..1308816 + 708 WP_031604554.1 tail assembly protein -
A7S67_RS06315 (1308888) 1308888..1312301 + 3414 WP_259407088.1 host specificity protein J -
A7S67_RS06320 (1312368) 1312368..1312802 - 435 WP_058645148.1 transcriptional regulator Antitoxin
A7S67_RS06325 (1312831) 1312831..1313013 - 183 WP_070800844.1 type II toxin-antitoxin system HicA family toxin Toxin
A7S67_RS06330 (1313102) 1313102..1313983 + 882 WP_070794208.1 prophage tail fiber N-terminal domain-containing protein -
A7S67_RS06335 (1313994) 1313994..1314587 + 594 WP_070804872.1 DUF4376 domain-containing protein -
A7S67_RS06340 (1314695) 1314695..1315069 + 375 WP_058645172.1 DUF1353 domain-containing protein -
A7S67_RS06345 (1315346) 1315346..1315609 - 264 WP_058645171.1 hypothetical protein -
A7S67_RS06350 (1315609) 1315609..1316451 - 843 WP_259407089.1 S-type pyocin domain-containing protein -
A7S67_RS24360 (1316467) 1316467..1317723 - 1257 WP_259407090.1 colicin-like bacteriocin tRNase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1271801..1314587 42786


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(11-82)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6892.08 Da        Isoelectric Point: 10.4804

>T203080 WP_070800844.1 NZ_CP075125:c1313013-1312831 [Salmonella enterica]
MKYNEFRRWLIQQGAKFINAPDGGSHQRVILNGKESVFPCHGAKEMPEPLRKKILKDLGL

Download         Length: 183 bp

>T203080 NZ_CP075125:c1313013-1312831 [Salmonella enterica]
ATGAAATATAACGAGTTCAGGCGGTGGCTCATCCAACAGGGTGCAAAGTTCATAAATGCACCGGATGGCGGCAGCCATCA
GCGTGTCATACTGAACGGGAAAGAATCTGTATTTCCCTGCCATGGCGCCAAAGAAATGCCGGAGCCGCTCAGAAAGAAAA
TACTCAAGGATTTGGGGCTTTAA

Antitoxin


Download         Length: 145 a.a.        Molecular weight: 15777.18 Da        Isoelectric Point: 4.5833

>AT203080 WP_058645148.1 NZ_CP075125:c1312802-1312368 [Salmonella enterica]
MFNYAVKPEYDPATESWVVTCRDLPLFNSVSFSIDDALLEAVDGAIVALSIEIDARRPVPIASQPEEGEYVIHLPVLVVM
KAALHNAMISTGTRKSDLARTMGMKGPQIDRLLDVCHSSKVETVELALQQLNRTVQISVDNVAV

Download         Length: 435 bp

>AT203080 NZ_CP075125:c1312802-1312368 [Salmonella enterica]
ATGTTTAACTATGCTGTGAAACCTGAGTATGATCCCGCAACAGAAAGCTGGGTTGTCACATGCCGGGATCTGCCACTATT
TAACTCCGTGAGTTTCAGCATTGACGATGCGCTTCTTGAGGCGGTTGATGGTGCCATCGTTGCACTCTCAATCGAAATCG
ACGCACGCCGTCCAGTCCCCATCGCCAGCCAGCCCGAAGAAGGGGAGTATGTCATTCATCTTCCCGTTCTGGTTGTGATG
AAAGCCGCGCTGCATAATGCAATGATTTCCACAGGGACACGAAAATCCGATCTTGCCCGAACTATGGGGATGAAAGGTCC
CCAGATAGATCGCCTCCTGGATGTTTGCCACTCATCGAAAGTGGAAACAGTAGAACTCGCTCTTCAGCAACTCAACCGGA
CTGTACAGATAAGCGTTGATAACGTTGCGGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Z7XAV3

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z7XCZ9

References