Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 937447..938107 Replicon chromosome
Accession NZ_CP075125
Organism Salmonella enterica strain CFSAN044945

Toxin (Protein)


Gene name cptA Uniprot ID A0A3Y0E4E4
Locus tag A7S67_RS04515 Protein ID WP_000244757.1
Coordinates 937694..938107 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag A7S67_RS04510 Protein ID WP_000351186.1
Coordinates 937447..937713 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S67_RS04490 (933375) 933375..934808 - 1434 WP_001230152.1 6-phospho-beta-glucosidase BglA -
A7S67_RS04495 (934967) 934967..935278 + 312 WP_058344418.1 N(4)-acetylcytidine aminohydrolase -
A7S67_RS04500 (935442) 935442..936101 + 660 WP_000250289.1 hemolysin III family protein -
A7S67_RS04505 (936217) 936217..937197 - 981 WP_000874170.1 tRNA-modifying protein YgfZ -
A7S67_RS04510 (937447) 937447..937713 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
A7S67_RS04515 (937694) 937694..938107 + 414 WP_000244757.1 protein YgfX Toxin
A7S67_RS04520 (938160) 938160..938681 - 522 WP_001055885.1 flavodoxin FldB -
A7S67_RS04525 (938794) 938794..939690 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
A7S67_RS04530 (939714) 939714..940427 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
A7S67_RS04535 (940433) 940433..942166 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16282.29 Da        Isoelectric Point: 11.1741

>T203079 WP_000244757.1 NZ_CP075125:937694-938107 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISRQH

Download         Length: 414 bp

>T203079 NZ_CP099874:3482183-3482401 [Escherichia albertii]
ATGTCCGATAAACCTTTAACAAAAACCGATTATTTGATGCGTCTGCGTCGTTGCCAGACAATTGACACACTGGAACGTGT
TATCGAGAAAAATAAATATGAATTATCAGATAATGAATTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTTGCAGAGC
TGACTATGAATAAGCTATATGACAAGATCCCTTCCTCAGTGTGGAAATTCATTCGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT203079 WP_000351186.1 NZ_CP075125:937447-937713 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT203079 NZ_CP099874:3481783-3482157 [Escherichia albertii]
ATGGATGAATACTCACCAAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGTAACCATGGCTGGGTAAATGACCCAACCTCGGCAATCAATCTACAGCTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAACAGATTGATGAATATCTG
GACGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGCTCTTCAGAAATGGCGGAAGTCAGGTAACCGATT
GTTCCGTTGCTTTGTTAACGCCACCAAAGCGAATCCTGCAAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Y0E4E4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References