Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 201360..202120 Replicon chromosome
Accession NZ_CP075125
Organism Salmonella enterica strain CFSAN044945

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag A7S67_RS00945 Protein ID WP_000533909.1
Coordinates 201635..202120 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag A7S67_RS00940 Protein ID WP_000965886.1
Coordinates 201360..201647 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S67_RS24305 (197362) 197362..197817 + 456 Protein_183 IS3 family transposase -
A7S67_RS24310 (197941) 197941..198729 + 789 Protein_184 IS3 family transposase -
A7S67_RS00930 (199287) 199287..200030 + 744 WP_001646634.1 HNH endonuclease -
A7S67_RS00935 (200101) 200101..200727 - 627 WP_130559547.1 hypothetical protein -
A7S67_RS00940 (201360) 201360..201647 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
A7S67_RS00945 (201635) 201635..202120 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
A7S67_RS00950 (202492) 202492..203031 - 540 WP_000047140.1 copper-binding periplasmic metallochaperone CueP -
A7S67_RS00955 (203204) 203204..203416 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
A7S67_RS00960 (203704) 203704..203994 - 291 WP_000455790.1 HTH-type transcriptional regulator -
A7S67_RS00965 (204433) 204433..205143 + 711 WP_000190524.1 DUF3053 domain-containing protein -
A7S67_RS00970 (205193) 205193..206167 - 975 WP_000804695.1 glyoxylate/hydroxypyruvate reductase GhrB -
A7S67_RS00975 (206386) 206386..207048 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T203078 WP_000533909.1 NZ_CP075125:201635-202120 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T203078 NZ_CP099874:2439264-2439542 [Escherichia albertii]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCTGCAAGCAGTCTTGTTGATATCGATATGCCCGGTTACCGACTAC
ACCCATTAAGCGGCGATCGCGATGGCATCTGGGCAATATCTGTATCAGGCAACTGGCGAATCACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT203078 WP_000965886.1 NZ_CP075125:201360-201647 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT203078 NZ_CP099874:2439542-2439826 [Escherichia albertii]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGACTGTTGACCGGAAAAGCGGCTTTGACGCCAGAAATGGCGA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCTGAG
AAAACGGTGGATGTGTCGCGGTTGCGCCGTCTGGTTGCGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References