Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4179182..4179963 Replicon chromosome
Accession NZ_CP075122
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN051827

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag BCA48_RS20310 Protein ID WP_000626100.1
Coordinates 4179182..4179673 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag BCA48_RS20315 Protein ID WP_001110452.1
Coordinates 4179670..4179963 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCA48_RS20275 (4174642) 4174642..4174989 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
BCA48_RS20280 (4174965) 4174965..4176668 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
BCA48_RS20285 (4176705) 4176705..4177280 + 576 WP_001188509.1 transcriptional regulator -
BCA48_RS20295 (4177551) 4177551..4177625 - 75 Protein_3985 helix-turn-helix domain-containing protein -
BCA48_RS20300 (4178005) 4178005..4178082 + 78 Protein_3986 porin family protein -
BCA48_RS20305 (4178182) 4178182..4178934 + 753 WP_000842433.1 non-specific acid phosphatase -
BCA48_RS20310 (4179182) 4179182..4179673 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
BCA48_RS20315 (4179670) 4179670..4179963 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
BCA48_RS20320 (4180280) 4180280..4180501 + 222 WP_001576552.1 hypothetical protein -
BCA48_RS20325 (4180767) 4180767..4181642 + 876 WP_000921676.1 AraC family transcriptional regulator -
BCA48_RS20330 (4181639) 4181639..4181926 + 288 WP_001541332.1 transcriptional regulator RtsB -
BCA48_RS20335 (4181919) 4181919..4182227 - 309 WP_072095651.1 ABC transporter ATP-binding protein -
BCA48_RS20340 (4182226) 4182226..4182474 + 249 Protein_3994 Ig-like domain-containing protein -
BCA48_RS23470 (4182586) 4182586..4182717 + 132 Protein_3995 hypothetical protein -
BCA48_RS20345 (4183011) 4183011..4183916 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T203073 WP_000626100.1 NZ_CP075122:c4179673-4179182 [Salmonella enterica subsp. enterica serovar Enteritidis]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T203073 NZ_CP099874:c812816-812439 [Escherichia albertii]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCACTACGGCCTCGCGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AAGCGGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACCGAACAGTAAATAACATTACTCTGGGTAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT203073 WP_001110452.1 NZ_CP075122:c4179963-4179670 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT203073 NZ_CP099874:c813274-812906 [Escherichia albertii]
GTGTCAGACACACTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTTGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References