Detailed information of TA system TA203072

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4072295..4072811
• Replicon: chromosome
• Accession: NZ_CP075122
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN051827

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B5R9I9
• Locus tag: BCA48_RS19740
• Protein ID: WP_000220582.1
• Coordinates: 4072295..4072579 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V7ISI8
• Locus tag: BCA48_RS19745
• Protein ID: WP_000212724.1
• Coordinates: 4072569..4072811 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BCA48_RS19725 (4067506)	4067506..4069158	+	1653	WP_000155048.1	alpha,alpha-phosphotrehalase	-
BCA48_RS19730 (4069567)	4069567..4071705	+	2139	WP_038425583.1	anaerobic ribonucleoside-triphosphate reductase	-
BCA48_RS19735 (4071827)	4071827..4072291	+	465	WP_001268859.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
BCA48_RS19740 (4072295)	4072295..4072579	-	285	WP_000220582.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BCA48_RS19745 (4072569)	4072569..4072811	-	243	WP_000212724.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
BCA48_RS19750 (4072889)	4072889..4074802	-	1914	WP_001212142.1	BglG family transcription antiterminator	-
BCA48_RS19755 (4074819)	4074819..4075559	-	741	WP_000779259.1	KDGP aldolase family protein	-
BCA48_RS19760 (4075556)	4075556..4076674	-	1119	WP_001139169.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
BCA48_RS19765 (4076658)	4076658..4077791	-	1134	WP_000459957.1	amidohydrolase/deacetylase family metallohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10912.66 Da
• Isoelectric Point: 9.6743

>T203072 WP_000220582.1 NZ_CP075122:c4072579-4072295 [Salmonella enterica subsp. enterica serovar Enteritidis]
MTYELEFDPRALKEWHKLGDTVQAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Nucleotide

• Length: 285 bp

>T203072 NZ_CP099874:635397-635711 [Escherichia albertii]
ATGCACCTGATCACTCAAAAAGCATTGAAAGATGCAGCGGAAAAATATCCGCAGCATAAAACGGAGTTGGTGGCACTGGG
GAACACGATTGCTAAGGGATACTTCAAAAAACCTGAGTCATTAAAAGCAGTGTTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCACAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8961.34 Da
• Isoelectric Point: 5.0651

>AT203072 WP_000212724.1 NZ_CP075122:c4072811-4072569 [Salmonella enterica subsp. enterica serovar Enteritidis]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT203072 NZ_CP099874:635708-636124 [Escherichia albertii]
ATGATTGCGATTGCCGATATCTTGCAAGCAGGAGAAAAGCTAACCGATGTGGCACCTTTTCTGGCGGGTATCCAGAGCGA
AGAACAGTATGCCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAATCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCTGAATTTAATGCGATGGTTCAAGCCATGCCTGGCGGT
GTTGCTGTGATTCGTACCCTGATGGATCAATACGGCTTAACCCTTTCCGATCTTCCAGAAATTGGCAGTAAATCCATGGT
GTCACGCGTTTTGAACGGGAAGAGAAAATTAACGCTGGAACACGCTAAAAAACTGGCAGCGCGATTCGGCATTTCCCCTG
CGTTGTTTATTGATTAA

Structures

Toxin

• AlphaFold DB: A0A656ILJ8

Antitoxin

• AlphaFold DB: A0A5H5JRI5