Detailed information of TA system TA203066

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3405346..3405966
• Replicon: chromosome
• Accession: NZ_CP075122
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN051827

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: BCA48_RS16660
• Protein ID: WP_001280991.1
• Coordinates: 3405748..3405966 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: BCA48_RS16655
• Protein ID: WP_000344807.1
• Coordinates: 3405346..3405720 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BCA48_RS16645 (3400485)	3400485..3401678	+	1194	WP_001039202.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-
BCA48_RS16650 (3401701)	3401701..3404850	+	3150	WP_001132508.1	efflux RND transporter permease AcrB	-
BCA48_RS16655 (3405346)	3405346..3405720	+	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
BCA48_RS16660 (3405748)	3405748..3405966	+	219	WP_001280991.1	HHA domain-containing protein	Toxin
BCA48_RS16665 (3406145)	3406145..3406696	+	552	WP_001278793.1	maltose O-acetyltransferase	-
BCA48_RS16670 (3406814)	3406814..3407284	+	471	WP_000136183.1	YlaC family protein	-
BCA48_RS16675 (3407340)	3407340..3407480	-	141	WP_001197749.1	type B 50S ribosomal protein L36	-
BCA48_RS16680 (3407486)	3407486..3407746	-	261	WP_000801412.1	type B 50S ribosomal protein L31	-
BCA48_RS16685 (3407971)	3407971..3409521	+	1551	WP_000213140.1	EAL domain-containing protein	-
BCA48_RS16695 (3409752)	3409752..3410141	+	390	WP_000961287.1	MGMT family protein	-
BCA48_RS16700 (3410174)	3410174..3410743	-	570	WP_000779802.1	YbaY family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T203066 WP_001280991.1 NZ_CP075122:3405748-3405966 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T203066 NZ_CP099872:c131344-131039 [Escherichia albertii]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGTATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGGGAAAATGACATCAAAAATGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT203066 WP_000344807.1 NZ_CP075122:3405346-3405720 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT203066 NZ_CP099872:c131564-131346 [Escherichia albertii]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGCTGCTCAAGGCGTATGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGGCGACTGCGCGCTGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCAG
AGGTCGCTAGGTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0