Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 14497..15022 Replicon plasmid pCFSAN051882
Accession NZ_CP075121
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN051882

Toxin (Protein)


Gene name ccdB Uniprot ID I3W3D5
Locus tag BCB01_RS22695 Protein ID WP_001159863.1
Coordinates 14497..14802 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7S5D0
Locus tag BCB01_RS22700 Protein ID WP_000813641.1
Coordinates 14804..15022 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCB01_RS22655 (BCB01_022660) 9876..10436 - 561 WP_000900095.1 inverse autotransporter beta domain-containing protein -
BCB01_RS22660 (BCB01_022665) 10592..10879 + 288 WP_071530243.1 hypothetical protein -
BCB01_RS22665 (BCB01_022670) 11156..11641 - 486 WP_000905606.1 membrane protein -
BCB01_RS22670 (BCB01_022675) 11635..12123 - 489 WP_001075507.1 CaiF/GrlA family transcriptional regulator -
BCB01_RS22675 (BCB01_022680) 12148..12861 - 714 WP_000545756.1 EAL domain-containing protein -
BCB01_RS22680 (BCB01_022685) 12870..13652 - 783 WP_000082169.1 site-specific integrase -
BCB01_RS22685 (BCB01_022690) 13687..14208 - 522 WP_000198608.1 hypothetical protein -
BCB01_RS22690 (BCB01_022695) 14205..14495 - 291 WP_001266176.1 hypothetical protein -
BCB01_RS22695 (BCB01_022700) 14497..14802 - 306 WP_001159863.1 type II toxin-antitoxin system toxin CcdB Toxin
BCB01_RS22700 (BCB01_022705) 14804..15022 - 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
BCB01_RS22705 (BCB01_022710) 15698..16219 + 522 WP_077681952.1 hypothetical protein -
BCB01_RS22710 (BCB01_022715) 16263..16691 - 429 Protein_23 hypothetical protein -
BCB01_RS22715 (BCB01_022720) 16703..16998 + 296 Protein_24 cytoplasmic protein -
BCB01_RS22720 (BCB01_022725) 17492..18481 + 990 WP_000461382.1 RepB family plasmid replication initiator protein -
BCB01_RS22725 (BCB01_022730) 18850..18969 - 120 Protein_26 recombinase -
BCB01_RS22730 (BCB01_022735) 19022..19408 - 387 WP_000751876.1 YgiW/YdeI family stress tolerance OB fold protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - spvB / spvC / fdeC / pefB / pefA / pefC / pefD / rck / rck 1..61453 61453


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11587.48 Da        Isoelectric Point: 6.9787

>T203049 WP_001159863.1 NZ_CP075121:c14802-14497 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI

Download         Length: 306 bp

>T203049 NZ_CP099868:4088561-4088902 [Escherichia albertii]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCACCCAACCACCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGAGTTTATTGGGGTAATTAC
AGGTAAACAGAAAGTCGCCTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8314.16 Da        Isoelectric Point: 4.5203

>AT203049 WP_000813641.1 NZ_CP075121:c15022-14804 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADDNRNW

Download         Length: 219 bp

>AT203049 NZ_CP099868:c4088566-4088490 [Escherichia albertii]
AGTCATGATTACTATTCTCCAGAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I3W3D5

Antitoxin

Source ID Structure
AlphaFold DB A0A656ICA6

References