Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 14497..15022 | Replicon | plasmid pCFSAN051882 |
| Accession | NZ_CP075121 | ||
| Organism | Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN051882 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | I3W3D5 |
| Locus tag | BCB01_RS22695 | Protein ID | WP_001159863.1 |
| Coordinates | 14497..14802 (-) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | M7S5D0 |
| Locus tag | BCB01_RS22700 | Protein ID | WP_000813641.1 |
| Coordinates | 14804..15022 (-) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BCB01_RS22655 (BCB01_022660) | 9876..10436 | - | 561 | WP_000900095.1 | inverse autotransporter beta domain-containing protein | - |
| BCB01_RS22660 (BCB01_022665) | 10592..10879 | + | 288 | WP_071530243.1 | hypothetical protein | - |
| BCB01_RS22665 (BCB01_022670) | 11156..11641 | - | 486 | WP_000905606.1 | membrane protein | - |
| BCB01_RS22670 (BCB01_022675) | 11635..12123 | - | 489 | WP_001075507.1 | CaiF/GrlA family transcriptional regulator | - |
| BCB01_RS22675 (BCB01_022680) | 12148..12861 | - | 714 | WP_000545756.1 | EAL domain-containing protein | - |
| BCB01_RS22680 (BCB01_022685) | 12870..13652 | - | 783 | WP_000082169.1 | site-specific integrase | - |
| BCB01_RS22685 (BCB01_022690) | 13687..14208 | - | 522 | WP_000198608.1 | hypothetical protein | - |
| BCB01_RS22690 (BCB01_022695) | 14205..14495 | - | 291 | WP_001266176.1 | hypothetical protein | - |
| BCB01_RS22695 (BCB01_022700) | 14497..14802 | - | 306 | WP_001159863.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| BCB01_RS22700 (BCB01_022705) | 14804..15022 | - | 219 | WP_000813641.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| BCB01_RS22705 (BCB01_022710) | 15698..16219 | + | 522 | WP_077681952.1 | hypothetical protein | - |
| BCB01_RS22710 (BCB01_022715) | 16263..16691 | - | 429 | Protein_23 | hypothetical protein | - |
| BCB01_RS22715 (BCB01_022720) | 16703..16998 | + | 296 | Protein_24 | cytoplasmic protein | - |
| BCB01_RS22720 (BCB01_022725) | 17492..18481 | + | 990 | WP_000461382.1 | RepB family plasmid replication initiator protein | - |
| BCB01_RS22725 (BCB01_022730) | 18850..18969 | - | 120 | Protein_26 | recombinase | - |
| BCB01_RS22730 (BCB01_022735) | 19022..19408 | - | 387 | WP_000751876.1 | YgiW/YdeI family stress tolerance OB fold protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | spvB / spvC / fdeC / pefB / pefA / pefC / pefD / rck / rck | 1..61453 | 61453 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11587.48 Da Isoelectric Point: 6.9787
>T203049 WP_001159863.1 NZ_CP075121:c14802-14497 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI
Download Length: 306 bp
>T203049 NZ_CP099868:4088561-4088902 [Escherichia albertii]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCACCCAACCACCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGAGTTTATTGGGGTAATTAC
AGGTAAACAGAAAGTCGCCTGA
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCACCCAACCACCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGAGTTTATTGGGGTAATTAC
AGGTAAACAGAAAGTCGCCTGA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8314.16 Da Isoelectric Point: 4.5203
>AT203049 WP_000813641.1 NZ_CP075121:c15022-14804 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADDNRNW
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADDNRNW
Download Length: 219 bp
>AT203049 NZ_CP099868:c4088566-4088490 [Escherichia albertii]
AGTCATGATTACTATTCTCCAGAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
AGTCATGATTACTATTCTCCAGAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | I3W3D5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A656ICA6 |