Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4178794..4179575 Replicon chromosome
Accession NZ_CP075120
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN051882

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag BCB01_RS20310 Protein ID WP_000626100.1
Coordinates 4178794..4179285 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag BCB01_RS20315 Protein ID WP_001110452.1
Coordinates 4179282..4179575 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCB01_RS20275 (4174254) 4174254..4174601 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
BCB01_RS20280 (4174577) 4174577..4176280 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
BCB01_RS20285 (4176317) 4176317..4176892 + 576 WP_001188509.1 transcriptional regulator -
BCB01_RS20295 (4177163) 4177163..4177237 - 75 Protein_3984 helix-turn-helix domain-containing protein -
BCB01_RS20300 (4177617) 4177617..4177694 + 78 Protein_3985 porin family protein -
BCB01_RS20305 (4177794) 4177794..4178546 + 753 WP_000842433.1 non-specific acid phosphatase -
BCB01_RS20310 (4178794) 4178794..4179285 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
BCB01_RS20315 (4179282) 4179282..4179575 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
BCB01_RS20320 (4179892) 4179892..4180113 + 222 WP_031612839.1 hypothetical protein -
BCB01_RS20325 (4180379) 4180379..4181254 + 876 WP_000921676.1 AraC family transcriptional regulator -
BCB01_RS20330 (4181251) 4181251..4181538 + 288 WP_001541332.1 transcriptional regulator RtsB -
BCB01_RS20335 (4181531) 4181531..4181839 - 309 WP_072095651.1 ABC transporter ATP-binding protein -
BCB01_RS20340 (4181838) 4181838..4182086 + 249 Protein_3993 Ig-like domain-containing protein -
BCB01_RS23240 (4182198) 4182198..4182329 + 132 Protein_3994 hypothetical protein -
BCB01_RS20345 (4182623) 4182623..4183528 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T203046 WP_000626100.1 NZ_CP075120:c4179285-4178794 [Salmonella enterica subsp. enterica serovar Enteritidis]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T203046 NZ_CP099868:3536693-3536911 [Escherichia albertii]
ATGTCCGATAAACCTTTAACAAAAACCGATTATTTGATGCGTCTGCGTCGTTGCCAGACAATTGACACACTGGAACGTGT
TATCGAGAAAAATAAATATGAATTATCAGATAATGAATTGGCGGTATTTTACTCAGCTGCCGACCATCGGCTTGCAGAGC
TGACTATGAATAAGCTATATGACAAGATCCCTTCCTCAGTGTGGAAATTCATTCGGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT203046 WP_001110452.1 NZ_CP075120:c4179575-4179282 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT203046 NZ_CP099868:3536293-3536667 [Escherichia albertii]
ATGGATGAATACTCACCAAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGTAACCATGGCTGGGTAAATGACCCAACCTCGGCAATCAATCTACAGCTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAACAGATTGATGAATATCTG
GACGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAACCGATT
GTTCCGTTGCTTTGTTAACGCCACCAAAGCGAATCCTGCAAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References