Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4030784..4031334 Replicon chromosome
Accession NZ_CP075120
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN051882

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag BCB01_RS19530 Protein ID WP_001199743.1
Coordinates 4030784..4031092 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag BCB01_RS19535 Protein ID WP_001118105.1
Coordinates 4031095..4031334 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCB01_RS19510 (4027358) 4027358..4028098 - 741 WP_001676217.1 SEF14/SEF18 fimbria chaperone SefB -
BCB01_RS19515 (4028220) 4028220..4028750 - 531 WP_000909461.1 SEF14 fimbria major subunit SefA -
BCB01_RS19520 (4029073) 4029073..4030206 + 1134 Protein_3833 IS3 family transposase -
BCB01_RS19525 (4030238) 4030238..4030378 - 141 Protein_3834 Arm DNA-binding domain-containing protein -
BCB01_RS19530 (4030784) 4030784..4031092 - 309 WP_001199743.1 CcdB family protein Toxin
BCB01_RS19535 (4031095) 4031095..4031334 - 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
BCB01_RS19540 (4031443) 4031443..4031691 - 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
BCB01_RS19545 (4031882) 4031882..4032313 - 432 Protein_3838 helix-turn-helix domain-containing protein -
BCB01_RS19555 (4033070) 4033070..4034089 + 1020 WP_001708525.1 NAD(P)-dependent alcohol dehydrogenase -
BCB01_RS19560 (4034117) 4034117..4034647 - 531 WP_000896758.1 gluconokinase -
BCB01_RS19565 (4034864) 4034864..4035895 + 1032 WP_000453347.1 L-idonate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4011375..4031691 20316
- inside IScluster/Tn - - 4029165..4032268 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T203044 WP_001199743.1 NZ_CP075120:c4031092-4030784 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T203044 NZ_CP099868:2476478-2476756 [Escherichia albertii]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCAAGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ACCCATTAAGCGGCGATCGCGATGGCATCTGGGCAATATCTGTATCAGGCAACTGGCGAATCACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT203044 WP_001118105.1 NZ_CP075120:c4031334-4031095 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT203044 NZ_CP099868:2476756-2477040 [Escherichia albertii]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGACTGTTGACCGGAAAAGCGGCTTTGACGCCAGAAATGGCGA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCTGAG
AAAACGGTGGATGTGTCGCGGTTGCGCCGTCTGGTTGCGCAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References