Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3405236..3405856 Replicon chromosome
Accession NZ_CP075120
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN051882

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag BCB01_RS16670 Protein ID WP_001280991.1
Coordinates 3405638..3405856 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag BCB01_RS16665 Protein ID WP_000344807.1
Coordinates 3405236..3405610 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCB01_RS16655 (3400375) 3400375..3401568 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
BCB01_RS16660 (3401591) 3401591..3404740 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
BCB01_RS16665 (3405236) 3405236..3405610 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
BCB01_RS16670 (3405638) 3405638..3405856 + 219 WP_001280991.1 HHA domain-containing protein Toxin
BCB01_RS16675 (3406035) 3406035..3406586 + 552 WP_001278793.1 maltose O-acetyltransferase -
BCB01_RS16680 (3406704) 3406704..3407174 + 471 WP_000136183.1 YlaC family protein -
BCB01_RS16685 (3407230) 3407230..3407370 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
BCB01_RS16690 (3407376) 3407376..3407636 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
BCB01_RS16695 (3407861) 3407861..3409411 + 1551 WP_000213140.1 EAL domain-containing protein -
BCB01_RS16705 (3409642) 3409642..3410031 + 390 WP_000961287.1 MGMT family protein -
BCB01_RS16710 (3410064) 3410064..3410633 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T203039 WP_001280991.1 NZ_CP075120:3405638-3405856 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T203039 NZ_CP099868:1054494-1054646 [Escherichia albertii]
ATGCTAACAAAATATGCCCTTGTGGCAATCATCGTACTGTGTTGTACAGTACTGGGATTCACGCTGATGGTAGGCGACTC
GCTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT203039 WP_000344807.1 NZ_CP075120:3405236-3405610 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT203039 NZ_CP099868:c1054452-1054400 [Escherichia albertii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References