Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4031123..4031673 Replicon chromosome
Accession NZ_CP075118
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN051890

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag BCB09_RS19530 Protein ID WP_001199743.1
Coordinates 4031123..4031431 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag BCB09_RS19535 Protein ID WP_001118105.1
Coordinates 4031434..4031673 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCB09_RS19510 (4027697) 4027697..4028437 - 741 WP_001676217.1 SEF14/SEF18 fimbria chaperone SefB -
BCB09_RS19515 (4028559) 4028559..4029089 - 531 WP_000909461.1 SEF14 fimbria major subunit SefA -
BCB09_RS19520 (4029412) 4029412..4030545 + 1134 Protein_3833 IS3 family transposase -
BCB09_RS19525 (4030577) 4030577..4030717 - 141 Protein_3834 Arm DNA-binding domain-containing protein -
BCB09_RS19530 (4031123) 4031123..4031431 - 309 WP_001199743.1 CcdB family protein Toxin
BCB09_RS19535 (4031434) 4031434..4031673 - 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
BCB09_RS19540 (4031782) 4031782..4032030 - 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
BCB09_RS19545 (4032221) 4032221..4032652 - 432 Protein_3838 helix-turn-helix domain-containing protein -
BCB09_RS19555 (4033409) 4033409..4034428 + 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
BCB09_RS19560 (4034456) 4034456..4034986 - 531 WP_000896758.1 gluconokinase -
BCB09_RS19565 (4035203) 4035203..4036234 + 1032 WP_000453347.1 L-idonate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 4029504..4032607 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T203017 WP_001199743.1 NZ_CP075118:c4031431-4031123 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T203017 NZ_CP099834:1858770-1858872 [Klebsiella quasipneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT203017 WP_001118105.1 NZ_CP075118:c4031673-4031434 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT203017 NZ_CP099834:c1858876-1858729 [Klebsiella quasipneumoniae]
AGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTG
GCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGTCTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References