Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3980855..3981431 Replicon chromosome
Accession NZ_CP075118
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN051890

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag BCB09_RS19305 Protein ID WP_001131963.1
Coordinates 3981144..3981431 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag BCB09_RS19300 Protein ID WP_000063142.1
Coordinates 3980855..3981157 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCB09_RS19285 (3977365) 3977365..3979515 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
BCB09_RS19290 (3979610) 3979610..3979813 + 204 WP_000460616.1 YbdD/YjiX family protein -
BCB09_RS19295 (3979824) 3979824..3980780 + 957 WP_000187843.1 GTPase -
BCB09_RS19300 (3980855) 3980855..3981157 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
BCB09_RS19305 (3981144) 3981144..3981431 - 288 WP_001131963.1 BrnT family toxin Toxin
BCB09_RS19310 (3981855) 3981855..3983696 + 1842 WP_000974637.1 nuclease-related domain-containing DEAD/DEAH box helicase -
BCB09_RS19315 (3984309) 3984309..3984884 + 576 WP_000593784.1 restriction endonuclease subunit S -
BCB09_RS19320 (3984889) 3984889..3986142 + 1254 WP_001206755.1 N-6 DNA methylase -
BCB09_RS23295 (3986174) 3986174..3986308 - 135 WP_001055725.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T203016 WP_001131963.1 NZ_CP075118:c3981431-3981144 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T203016 NZ_CP099834:786725-787135 [Klebsiella quasipneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTCCACGGCGTTGTAGCGGC
GCTGGTGCTGCTGGTTCCCTGGCCGTTAAGCTACACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTTGACTGTG
TGCGCAGCCAGCGACGGATTCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGGCTGCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTCATCAACAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGACGCGG
TCAGCATCTGTGGCTGGCGGCGGACAGCATGGATCCCGGAGAGTGGCGGGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT203016 WP_000063142.1 NZ_CP075118:c3981157-3980855 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT203016 NZ_CP099834:786478-786744 [Klebsiella quasipneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References