Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3405327..3405947 Replicon chromosome
Accession NZ_CP075118
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN051890

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag BCB09_RS16660 Protein ID WP_001280991.1
Coordinates 3405729..3405947 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag BCB09_RS16655 Protein ID WP_000344807.1
Coordinates 3405327..3405701 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCB09_RS16645 (3400466) 3400466..3401659 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
BCB09_RS16650 (3401682) 3401682..3404831 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
BCB09_RS16655 (3405327) 3405327..3405701 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
BCB09_RS16660 (3405729) 3405729..3405947 + 219 WP_001280991.1 HHA domain-containing protein Toxin
BCB09_RS16665 (3406126) 3406126..3406677 + 552 WP_001278793.1 maltose O-acetyltransferase -
BCB09_RS16670 (3406795) 3406795..3407265 + 471 WP_000136183.1 YlaC family protein -
BCB09_RS16675 (3407321) 3407321..3407461 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
BCB09_RS16680 (3407467) 3407467..3407727 - 261 WP_000801412.1 type B 50S ribosomal protein L31 -
BCB09_RS16685 (3407952) 3407952..3409502 + 1551 WP_000213140.1 EAL domain-containing protein -
BCB09_RS16695 (3409733) 3409733..3410122 + 390 WP_000961287.1 MGMT family protein -
BCB09_RS16700 (3410155) 3410155..3410724 - 570 WP_076916856.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T203012 WP_001280991.1 NZ_CP075118:3405729-3405947 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T203012 NZ_CP099815:c958170-957967 [Yersinia ruckeri]
ATGACCAAAACTGACTACCTAATGCGTTTAAGAAAATGCACAACAATTGACACACTAGAGCGTGTTATTGAAAAAAATAA
GTATGAGCTATCTGATGATGAACTAGAATTATTCTATTCTGCTGCGGATCATCGTCTAGCTGAACTTACCATGAATAAGT
TATACGATAAAATTCCTGCAACTGTCTGGCAACATGTGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT203012 WP_000344807.1 NZ_CP075118:3405327-3405701 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT203012 NZ_CP099815:c958590-958222 [Yersinia ruckeri]
ATGGATGAGTACTCACCTAAGCGACATGATATTGCTCAGTTGAAATTCTTATGTGAGAATTTGTATGATGAAGGTATCGC
CACATTGGGCGATAGCCACCACGGCTGGGTTAATGATCCAACCTCCGCGGTAAATCTCCAACTGAATGATTTAATCGAAC
ACATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACGCAGACGAAATCGATCTCTGCGAGTTGGTGGAGGAATATCTA
GACGATACATATACCTTGTTCAGCAGTTACGGAATCAATGATCCTGATTTACGCCGCTGGCAGAAAACAAAAGACCGATT
ATTCAGACTATTTTCAGGGGAATACCTATGTGCCCTGATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References