202993

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4054750..4055266 Replicon chromosome
Accession NZ_CP075116
Organism Salmonella enterica subsp. enterica serovar Stanleyville strain CFSAN059881

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag CCO40_RS19410 Protein ID WP_000220578.1
Coordinates 4054750..4055034 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag CCO40_RS19415 Protein ID WP_000212724.1
Coordinates 4055024..4055266 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCO40_RS19395 (4049866) 4049866..4051518 + 1653 WP_061378443.1 alpha,alpha-phosphotrehalase -
CCO40_RS19400 (4051927) 4051927..4054065 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
CCO40_RS19405 (4054282) 4054282..4054746 + 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
CCO40_RS19410 (4054750) 4054750..4055034 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CCO40_RS19415 (4055024) 4055024..4055266 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CCO40_RS19420 (4055344) 4055344..4057257 - 1914 WP_001212135.1 BglG family transcription antiterminator -
CCO40_RS19425 (4057274) 4057274..4058014 - 741 WP_094889043.1 KDGP aldolase family protein -
CCO40_RS19430 (4058011) 4058011..4059129 - 1119 WP_094889044.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
CCO40_RS19435 (4059113) 4059113..4060246 - 1134 WP_079986648.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T202993 WP_000220578.1 NZ_CP075116:c4055034-4054750 [Salmonella enterica subsp. enterica serovar Stanleyville]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T202993 NZ_CP099809:c2060734-2060641 [Yersinia ruckeri]
TAAGCCTGCATGAAATGCCAACTTTTAGCGCACGGCTCTATCCCAAGAGCCATTTCCCTGGACCGAATATAGGATTCGTA
TTCGGTCTTTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT202993 WP_000212724.1 NZ_CP075116:c4055266-4055024 [Salmonella enterica subsp. enterica serovar Stanleyville]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT202993 NZ_CP099809:2060637-2060783 [Yersinia ruckeri]
AGTTAAAAAAAGACCGAATACGAATCCTATATTCGGTCCAGGGAAATGGCTCTTGGGATAGAGCCGTGCGCTAAAAGTTG
GCATTTCATGCAGGCTTATTAAGCCGTACCACTTAAGCGTAGTAGACGACCCACATTTTACCAATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References